Interplay between platelets and coagulation
Haemostasis stops bleeding at the site of vascular injury and maintains the integrity of blood
vessels through clot formation. This regulated physiological process consists of complex …
vessels through clot formation. This regulated physiological process consists of complex …
Malaria: biology and disease
Malaria has been a major global health problem of humans through history and is a leading
cause of death and disease across many tropical and subtropical countries. Over the last …
cause of death and disease across many tropical and subtropical countries. Over the last …
Disseminated intravascular coagulation
S Gando, M Levi, CH Toh - Nature reviews Disease primers, 2016 - nature.com
Disseminated intravascular coagulation (DIC) is an acquired syndrome characterized by
widespread intravascular activation of coagulation that can be caused by infectious insults …
widespread intravascular activation of coagulation that can be caused by infectious insults …
Innate immune receptors in platelets and platelet-leukocyte interactions
PRB Dib, AC Quirino-Teixeira, LB Merij… - Journal of Leucocyte …, 2020 - academic.oup.com
Platelets are chief cells in hemostasis. Apart from their hemostatic roles, platelets are major
inflammatory effector cells that can influence both innate and adaptive immune responses …
inflammatory effector cells that can influence both innate and adaptive immune responses …
Brain swelling and death in children with cerebral malaria
Background Case fatality rates among African children with cerebral malaria remain in the
range of 15 to 25%. The key pathogenetic processes and causes of death are unknown, but …
range of 15 to 25%. The key pathogenetic processes and causes of death are unknown, but …
Cerebral Plasmodium falciparum malaria: The role of PfEMP1 in its pathogenesis and immunity, and PfEMP1‐based vaccines to prevent it
Malaria, a mosquito‐borne infectious disease caused by parasites of the genus Plasmodium
continues to be a major health problem worldwide. The unicellular Plasmodium‐parasites …
continues to be a major health problem worldwide. The unicellular Plasmodium‐parasites …
Activated protein C: biased for translation
The homeostatic blood protease, activated protein C (APC), can function as (1) an
antithrombotic on the basis of inactivation of clotting factors Va and VIIIa;(2) a cytoprotective …
antithrombotic on the basis of inactivation of clotting factors Va and VIIIa;(2) a cytoprotective …
Endothelial thrombomodulin downregulation caused by hypoxia contributes to severe infiltration and coagulopathy in COVID-19 patient lungs
Background Thromboembolism is a life-threatening manifestation of coronavirus disease
2019 (COVID-19). We investigated a dysfunctional phenotype of vascular endothelial cells …
2019 (COVID-19). We investigated a dysfunctional phenotype of vascular endothelial cells …
New insights into malaria pathogenesis
Malaria remains a major public health threat in tropical and subtropical regions across the
world. Even though less than 1% of malaria infections are fatal, this leads to about 430,000 …
world. Even though less than 1% of malaria infections are fatal, this leads to about 430,000 …
Investigating the pathogenesis of severe malaria: a multidisciplinary and cross-geographical approach
More than a century after the discovery of Plasmodium spp. parasites, the pathogenesis of
severe malaria is still not well understood. The majority of malaria cases are caused by …
severe malaria is still not well understood. The majority of malaria cases are caused by …