Structure, function, and pharmacology of glutamate receptor ion channels
Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
The AMPA receptor code of synaptic plasticity
Changes in the properties and postsynaptic abundance of AMPA-type glutamate receptors
(AMPARs) are major mechanisms underlying various forms of synaptic plasticity, including …
(AMPARs) are major mechanisms underlying various forms of synaptic plasticity, including …
Structural and functional architecture of AMPA-type glutamate receptors and their auxiliary proteins
AMPA receptors (AMPARs) are tetrameric ion channels that together with other ionotropic
glutamate receptors (iGluRs), the NMDA and kainate receptors, mediate a majority of …
glutamate receptors (iGluRs), the NMDA and kainate receptors, mediate a majority of …
ABHD17 proteins are novel protein depalmitoylases that regulate N-Ras palmitate turnover and subcellular localization
DTS Lin, E Conibear - elife, 2015 - elifesciences.org
Dynamic changes in protein S-palmitoylation are critical for regulating protein localization
and signaling. Only two enzymes-the acyl-protein thioesterases APT1 and APT2–are known …
and signaling. Only two enzymes-the acyl-protein thioesterases APT1 and APT2–are known …
Architecture and subunit arrangement of native AMPA receptors elucidated by cryo-EM
Glutamate-gated AMPA receptors mediate the fast component of excitatory signal
transduction at chemical synapses throughout all regions of the mammalian brain. AMPA …
transduction at chemical synapses throughout all regions of the mammalian brain. AMPA …
Specification of synaptic connectivity by cell surface interactions
The molecular diversification of cell surface molecules has long been postulated to impart
specific surface identities on neuronal cell types. The existence of unique cell surface …
specific surface identities on neuronal cell types. The existence of unique cell surface …
Hippocampal AMPA receptor assemblies and mechanism of allosteric inhibition
AMPA-selective glutamate receptors mediate the transduction of signals between the
neuronal circuits of the hippocampus. The trafficking, localization, kinetics and …
neuronal circuits of the hippocampus. The trafficking, localization, kinetics and …
A Noelin-organized extracellular network of proteins required for constitutive and context-dependent anchoring of AMPA-receptors
S Boudkkazi, J Schwenk, N Nakaya, A Brechet… - Neuron, 2023 - cell.com
Information processing and storage in the brain rely on AMPA-receptors (AMPARs) and their
context-dependent dynamics in synapses and extra-synaptic sites. We found that distribution …
context-dependent dynamics in synapses and extra-synaptic sites. We found that distribution …
Neurodevelopmental disorders associated with PSD-95 and its interaction partners
The postsynaptic density (PSD) is a massive protein complex, critical for synaptic strength
and plasticity in excitatory neurons. Here, the scaffolding protein PSD-95 plays a crucial role …
and plasticity in excitatory neurons. Here, the scaffolding protein PSD-95 plays a crucial role …
Modulation of GluA2–γ5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2
Synaptic complexes of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)
receptors (AMPARs) with auxiliary subunits mediate most excitatory neurotransmission and …
receptors (AMPARs) with auxiliary subunits mediate most excitatory neurotransmission and …