Acute myeloid leukaemia (AML), chronic lymphocytic leukaemia (CLL), and multiple
myeloma (MM) are age-related haematological malignancies with defined precursor states …

The bone marrow microenvironment, also known as the bone marrow niche, is a complex
network of cell types and acellular factors that supports normal hematopoiesis. For many …

Like normal hematopoietic stem cells, leukemic stem cells depend on their bone marrow
(BM) microenvironment for survival, but the underlying mechanisms remain largely …

Our study details the stepwise evolution of gilteritinib resistance in FLT3-mutated acute
myeloid leukemia (AML). Early resistance is mediated by the bone marrow …

Mesenchymal stromal cells (MSCs) are essential elements of the bone marrow (BM)
microenvironment, which have been widely implicated in pathways that contribute to …

Rationale: Reciprocal interactions between leukemic cells and bone marrow mesenchymal
stromal cells (BMMSC) remodel the normal niche into a malignant niche, leading to …

Acute myeloid leukemia (AML) is a heterogeneous disease characterized by genomic
aberrations in oncogenes, cytogenetic abnormalities, and an aberrant epigenetic landscape …

Bone marrow microenvironment (BMM) has been proven to have benefits for both normal
hematopoietic stem cell niche and pathological leukemic stem cell niche. In fact, the …

Acute myeloid leukaemia (AML) is a heterogeneous disease with one of the worst survival
rates of all cancers. The bone marrow microenvironment is increasingly being recognised as …

Cancer cells depend on a supportive niche (the tumor microenvironment) that promotes
tumor cell survival while protecting the malignant cells from therapeutic challenges and the …