Ferroptosis is a non-apoptotic cell death mechanism characterized by iron-dependent
membrane lipid peroxidation. Here, we review what is known about the cellular mechanisms …

Ferroptosis is a non-apoptotic form of regulated cell death characterized by the lethal
accumulation of iron-dependent membrane-localized lipid peroxides. It acts as an innate …

Every cell must satisfy basic requirements for nutrient sensing, utilization and recycling
through macromolecular breakdown to coordinate programmes for growth, repair and stress …

Ferroptosis is a distinct lipid peroxidation-dependent form of necrotic cell death. This
process has been increasingly contemplated as a new target for cancer therapy because of …

Ferroptosis is a pervasive non-apoptotic form of cell death highly relevant in various
degenerative diseases and malignancies. The hallmark of ferroptosis is uncontrolled and …

Although it is well described that mitochondria are at the epicentre of the energy demands of
a cell, it is becoming important to consider how each cell tailors its mitochondrial …

The discovery of the medicinal properties of platinum complexes has fueled the design and
synthesis of new anticancer metallodrugs endowed with unique modes of action (MoA) …

The interaction between nuclear receptor coactivator 4 (NCOA4) and the iron storage
protein ferritin is a crucial component of cellular iron homeostasis. The binding of NCOA4 to …

Hepatocellular carcinoma (HCC) remains a major global health burden, and sorafenib, a
multi-kinase inhibitor, has shown effectiveness in the treatment of HCC and is considered as …

Metabolic-associated fatty liver disease (MAFLD) is witnessing a global surge; however, it
still lacks effective pharmacological interventions. Fucoxanthin, a natural bioactive …