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Studying human nociceptors: from fundamentals to clinic
Chronic pain affects one in five of the general population and is the third most important
cause of disability-adjusted life-years globally. Unfortunately, treatment remains inadequate …
cause of disability-adjusted life-years globally. Unfortunately, treatment remains inadequate …
Induced pluripotent stem cell (iPSC)-based neurodegenerative disease models for phenotype recapitulation and drug screening
Neurodegenerative diseases represent a significant unmet medical need in our aging
society. There are no effective treatments for most of these diseases, and we know …
society. There are no effective treatments for most of these diseases, and we know …
Peripherin is a biomarker of axonal damage in peripheral nervous system disease
S Keddie, D Smyth, RYS Keh, MKL Chou, D Grant… - Brain, 2023 - academic.oup.com
Valid, responsive blood biomarkers specific to peripheral nerve damage would improve
management of peripheral nervous system (PNS) diseases. Neurofilament light chain (NfL) …
management of peripheral nervous system (PNS) diseases. Neurofilament light chain (NfL) …
Immune-mediated neuropathies
Since the discovery of an acute monophasic paralysis, later coined Guillain–Barré
syndrome, almost 100 years ago, and the discovery of chronic, steroid-responsive …
syndrome, almost 100 years ago, and the discovery of chronic, steroid-responsive …
Advances and challenges in modeling inherited peripheral neuropathies using iPSCs
J Van Lent, R Prior, G Pérez Siles, AN Cutrupi… - … & molecular medicine, 2024 - nature.com
Inherited peripheral neuropathies (IPNs) are a group of diseases associated with mutations
in various genes with fundamental roles in the development and function of peripheral …
in various genes with fundamental roles in the development and function of peripheral …
Exosomes from human adipose‐derived stem cells promote sciatic nerve regeneration via optimizing Schwann cell function
Human adipose‐derived stem cells (ASCs) have a potential for the treatment of peripheral
nerve injury. Recent studies demonstrated that stem cells can mediate therapeutic effect by …
nerve injury. Recent studies demonstrated that stem cells can mediate therapeutic effect by …
A humanized chemogenetic system inhibits murine pain-related behavior and hyperactivity in human sensory neurons
Hyperexcitability in sensory neurons is known to underlie many of the maladaptive changes
associated with persistent pain. Chemogenetics has shown promise as a means to suppress …
associated with persistent pain. Chemogenetics has shown promise as a means to suppress …
Overlap** central and peripheral nervous system syndromes in MOG antibody–associated disorders
Objective Antibodies to myelin oligodendrocyte glycoprotein (MOG) are associated with
CNS demyelination inclusive of optic neuritis (ON) and transverse myelitis (TM). To examine …
CNS demyelination inclusive of optic neuritis (ON) and transverse myelitis (TM). To examine …
Genetic pain loss disorders
Genetic pain loss includes congenital insensitivity to pain (CIP), hereditary sensory
neuropathies and, if autonomic nerves are involved, hereditary sensory and autonomic …
neuropathies and, if autonomic nerves are involved, hereditary sensory and autonomic …
Defining the functional role of NaV1. 7 in human nociception
Loss-of-function mutations in Na V 1.7 cause congenital insensitivity to pain (CIP); this
voltage-gated sodium channel is therefore a key target for analgesic drug development …
voltage-gated sodium channel is therefore a key target for analgesic drug development …