Recent developments in nanomaterials-based drug delivery and upgrading treatment of cardiovascular diseases

NA Mohamed, I Marei, S Crovella… - International Journal of …, 2022 - mdpi.com
Cardiovascular diseases (CVDs) are the leading causes of morbidity and mortality
worldwide. However, despite the recent developments in the management of CVDs, the …

The exosome-mediated PI3K/Akt/mTOR signaling pathway in neurological diseases

A Iranpanah, L Kooshki, SZ Moradi, L Saso, S Fakhri… - Pharmaceutics, 2023 - mdpi.com
As major public health concerns associated with a rapidly growing aging population,
neurodegenerative diseases (NDDs) and neurological diseases are important causes of …

Ligustrazine nanoparticle hitchhiking on neutrophils for enhanced therapy of cerebral ischemia‐reperfusion injury

Q Mu, K Yao, MZ Syeda, M Zhang, Q Cheng… - Advanced …, 2023 - Wiley Online Library
Ischemic stroke is a refractory disease that endangers human health and safety owing to
cerebral ischemia. Brain ischemia induces a series of inflammatory reactions. Neutrophils …

Exercise-induced neuroprotection against cerebral ischemia/reperfusion injury is mediated via alleviating inflammasome-induced pyroptosis

M Liu, L Luo, J Fu, J He, M Chen, Z He, J Jia - Experimental neurology, 2022 - Elsevier
As a primary nonpharmacological tool, exercise training is neuroprotective after
experimental ischemic stroke by relieving neuroinflammation. However, the specific …

Current trends and future perspectives of stroke management through integrating health care team and nanodrug delivery strategy

X Han, Y Qin, C Mei, F Jiao… - Frontiers in Cellular …, 2023 - frontiersin.org
Stroke is accounted as the second-most mortality and adult disability factor in worldwide,
while causes the bleeding promptly and lifetime consequences. The employed functional …

Application and utility of liposomal neuroprotective agents and biomimetic nanoparticles for the treatment of ischemic stroke

T Fukuta, N Oku, K Kogure - Pharmaceutics, 2022 - mdpi.com
Ischemic stroke is still one of the leading causes of high mortality and severe disability
worldwide. Therapeutic options for ischemic stroke and subsequent cerebral …

Gold nanoparticles in neurological diseases: A review of neuroprotection

MC Chiang, YP Yang, CJB Nicol, CJ Wang - International Journal of …, 2024 - mdpi.com
This review explores the diverse applications of gold nanoparticles (AuNPs) in neurological
diseases, with a specific focus on Alzheimer's disease (AD), Parkinson's disease (PD), and …

Thrombolytic therapy based on lyophilized platelet-derived nanocarriers for ischemic stroke

M Migliavacca, C Correa-Paz, M Pérez-Mato… - Journal of …, 2024 - Springer
Background Intravenous administration of fibrinolytic drugs, such as recombinant tissue
plasminogen activator (rtPA) is the standard treatment of acute thrombotic diseases …

Snap25 attenuates neuronal injury via reducing ferroptosis in acute ischemic stroke

W Si, B Sun, J Luo, Z Li, Y Dou, Q Wang - Experimental Neurology, 2023 - Elsevier
Due to the limited clinical treatment options for acute ischemic stroke (AIS), there is still an
urgent requirement for in-depth research on the pathogenesis of AIS and the development of …

Involvement of ceramide metabolism in cerebral ischemia

A Ouro, C Correa-Paz, E Maqueda… - Frontiers in Molecular …, 2022 - frontiersin.org
Ischemic stroke, caused by the interruption of blood flow to the brain and subsequent
neuronal death, represents one of the main causes of disability in worldwide. Although …