Few metabolites can claim a more central and versatile role in cell metabolism than acetyl
coenzyme A (acetyl-CoA). Acetyl-CoA is produced during nutrient catabolism to fuel the …

Steatotic liver disease (SLD) displays a dynamic and complex disease phenotype.
Consequently, the metabolic dysfunction-associated steatotic liver disease …

Caloric restriction that promotes weight loss is an effective strategy for treating non-alcoholic
fatty liver disease and improving insulin sensitivity in people with type 2 diabetes. Despite its …

Metabolic dysfunction–associated steatohepatitis (MASH) is a severe form of liver disease
that poses a global health threat because of its potential to progress to advanced fibrosis …

The pharmacological treatment of dyslipidemia, a major modifiable risk factor for develo**
atherosclerotic cardiovascular disease (ASCVD), remains a debated and controversial …

The metabolite acetyl-CoA is necessary for both lipid synthesis in the cytosol and histone
acetylation in the nucleus. The two canonical precursors to acetyl-CoA in the nuclear …

The activity of 5′-adenosine monophosphate-activated protein kinase (AMPK) is inversely
correlated with the cellular availability of glucose. When glucose levels are low, the …

Abstract Purpose of Review The aim of creating an orally active non-statin cholesterol-
lowering drug was achieved with bempedoic acid, a small linear molecule providing both a …

Hepatic de novo lipogenesis (DNL) is a fundamental physiologic process that is often
pathogenically elevated in metabolic disease. Treatment is limited by incomplete …

Complex multicellular organisms require a coordinated response from multiple tissues to
maintain whole-body homeostasis in the face of energetic stressors such as fasting, cold …