[HTML][HTML] Mammalian transient receptor potential TRPA1 channels: from structure to disease

K Talavera, JB Startek, J Alvarez-Collazo… - Physiological …, 2020 - journals.physiology.org
The transient receptor potential ankyrin (TRPA) channels are Ca 2+-permeable nonselective
cation channels remarkably conserved through the animal kingdom. Mammals have only …

Transient receptor potential channels as drug targets: from the science of basic research to the art of medicine

B Nilius, A Szallasi - Pharmacological reviews, 2014 - Elsevier
The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …

Cardiac mechano-electric coupling: acute effects of mechanical stimulation on heart rate and rhythm

TA Quinn, P Kohl - Physiological reviews, 2021 - journals.physiology.org
The heart is vital for biological function in almost all chordates, including humans. It beats
continually throughout our life, supplying the body with oxygen and nutrients while removing …

Trpa1

PM Zygmunt, ED Högestätt - … potential (TRP) cation channels: volume I, 2014 - Springer
The transient receptor potential ankyrin subtype 1 protein (TRPA1) is a nonselective cation
channel permeable to Ca 2+, Na+, and K+. TRPA1 is a promiscuous chemical nocisensor …

The TRPA1 channel in inflammatory and neuropathic pain and migraine

R Nassini, S Materazzi, S Benemei… - Reviews of Physiology …, 2014 - Springer
The transient receptor potential ankyrin 1 (TRPA1), a member of the TRP superfamily of
channels, is primarily localized to a subpopulation of primary sensory neurons of the …

The triggering pathway to insulin secretion: Functional similarities and differences between the human and the mouse β cells and their translational relevance

M Skelin Klemen, J Dolenšek, M Slak Rupnik, A Stožer - Islets, 2017 - Taylor & Francis
In β cells, stimulation by metabolic, hormonal, neuronal, and pharmacological factors is
coupled to secretion of insulin through different intracellular signaling pathways. Our …

[PDF][PDF] Antidiabetic activity of papaya leaf extract (Carica Papaya L.) isolated with maceration method in alloxan-induces diabetic mice

TI Solikhah, B Setiawan, DR Ismukada - Systematic Reviews in …, 2020 - academia.edu
Introduction: Diabetes mellitus is a metabolic disorder disease that is often found in the
world. Treatment with natural products can be an effective alternative in treating diabetes …

[HTML][HTML] Involvement of thermosensitive TRP channels in energy metabolism

K Uchida, K Dezaki, T Yoneshiro, T Watanabe… - The journal of …, 2017 - Elsevier
To date, 11 thermosensitive transient receptor potential (thermo-TRP) channels have been
identified. Recent studies have characterized the mechanism of thermosensing by thermo …

[HTML][HTML] Functional and physiopathological implications of TRP channels

T Smani, G Shapovalov, R Skryma… - … et Biophysica Acta (BBA …, 2015 - Elsevier
Abstract Transient Receptor Potential (TRP) channel proteins are a diverse family of proteins
that are expressed in many organisms, tissues and cell types. TRP channels respond to a …

New natural agonists of the transient receptor potential Ankyrin 1 (TRPA1) channel

C Legrand, JM Merlini, C de Senarclens-Bezençon… - Scientific reports, 2020 - nature.com
The transient receptor potential (TRP) channels family are cationic channels involved in
various physiological processes as pain, inflammation, metabolism, swallowing function, gut …