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Mitochondrial dynamics in health and disease: mechanisms and potential targets
W Chen, H Zhao, Y Li - Signal transduction and targeted therapy, 2023 - nature.com
Mitochondria are organelles that are able to adjust and respond to different stressors and
metabolic needs within a cell, showcasing their plasticity and dynamic nature. These …
metabolic needs within a cell, showcasing their plasticity and dynamic nature. These …
Resistance mechanisms to anti-PD cancer immunotherapy
The transformative success of antibodies targeting the PD-1 (programmed death 1)/B7-H1
(B7 homolog 1) pathway (anti-PD therapy) has revolutionized cancer treatment. However …
(B7 homolog 1) pathway (anti-PD therapy) has revolutionized cancer treatment. However …
[HTML][HTML] Linoleic acid potentiates CD8+ T cell metabolic fitness and antitumor immunity
CBN Lauson, S Tiberti, PA Corsetto, F Conte, P Tyagi… - Cell Metabolism, 2023 - cell.com
The metabolic state represents a major hurdle for an effective adoptive T cell therapy (ACT).
Indeed, specific lipids can harm CD8+ T cell (CTL) mitochondrial integrity, leading to …
Indeed, specific lipids can harm CD8+ T cell (CTL) mitochondrial integrity, leading to …
IL-10-expressing CAR T cells resist dysfunction and mediate durable clearance of solid tumors and metastases
Cytotoxic CD8+ T cells play a key role in the elimination of intracellular infections and
malignant cells and can provide long-term protective immunity. In the response to infection …
malignant cells and can provide long-term protective immunity. In the response to infection …
The role of mitochondrial fission in cardiovascular health and disease
JM Quiles, ÅB Gustafsson - Nature Reviews Cardiology, 2022 - nature.com
Mitochondria are organelles involved in the regulation of various important cellular
processes, ranging from ATP generation to immune activation. A healthy mitochondrial …
processes, ranging from ATP generation to immune activation. A healthy mitochondrial …
[HTML][HTML] Elevated glucose levels favor SARS-CoV-2 infection and monocyte response through a HIF-1α/glycolysis-dependent axis
COVID-19 can result in severe lung injury. It remained to be determined why diabetic
individuals with uncontrolled glucose levels are more prone to develop the severe form of …
individuals with uncontrolled glucose levels are more prone to develop the severe form of …