Polymer–drug conjugate therapeutics: advances, insights and prospects
Polymer–drug conjugates have long been a mainstay of the drug delivery field, with several
conjugates successfully translated into clinical practice. The conjugation of therapeutic …
conjugates successfully translated into clinical practice. The conjugation of therapeutic …
Polyprodrug nanomedicines: an emerging paradigm for cancer therapy
Nanomedicines have the potential to provide advanced therapeutic strategies in combating
tumors. Polymer‐prodrug‐based nanomedicines are particularly attractive in cancer …
tumors. Polymer‐prodrug‐based nanomedicines are particularly attractive in cancer …
An NIR Discrete Metallacycle constructed from Perylene Bisimide and Tetraphenylethylene Fluorophores for imaging‐guided cancer Radio‐chemotherapy
Y Ding, Z Tong, L **, B Ye, J Zhou, Z Sun… - Advanced …, 2022 - Wiley Online Library
To promote the clinical theranostic performances of platinum‐based anticancer drugs,
imaging capability is urgently desired, and their chemotherapeutic efficacy needs to be …
imaging capability is urgently desired, and their chemotherapeutic efficacy needs to be …
Mitochondria-specific drug release and reactive oxygen species burst induced by polyprodrug nanoreactors can enhance chemotherapy
W Zhang, X Hu, Q Shen, D **ng - Nature communications, 2019 - nature.com
Cancer cells exhibit slightly elevated levels of reactive oxygen species (ROS) compared with
normal cells, and approximately 90% of intracellular ROS is produced in mitochondria. In …
normal cells, and approximately 90% of intracellular ROS is produced in mitochondria. In …
ROS‐responsive polyprodrug nanoparticles for triggered drug delivery and effective cancer therapy
The application of nanoparticles (NPs) to drug delivery has led to the development of novel
nanotherapeutics for the treatment of various diseases including cancer. However, clinical …
nanotherapeutics for the treatment of various diseases including cancer. However, clinical …
Enhanced antitumor efficacy by a cascade of reactive oxygen species generation and drug release
Reactive oxygen species (ROS) can be used not only as a therapeutic agent for
chemodynamic therapy (CDT), but also as a stimulus to activate release of antitumor drugs …
chemodynamic therapy (CDT), but also as a stimulus to activate release of antitumor drugs …
Tumor‐specific drug release and reactive oxygen species generation for cancer chemo/chemodynamic combination therapy
The combination of chemotherapeutic drugs and reactive oxygen species (ROS) is a
promising strategy to achieve improved anticancer effect. Herein, a nanomedicine …
promising strategy to achieve improved anticancer effect. Herein, a nanomedicine …
Activatable immunoprotease nanorestimulator for second near-infrared photothermal immunotherapy of cancer
Photothermal immunotherapy is a combinational cancer therapy modality, wherein the
photothermal process can noninvasively ablate cancer and efficiently trigger cancer …
photothermal process can noninvasively ablate cancer and efficiently trigger cancer …
Self-assembling prodrugs
AG Cheetham, RW Chakroun, W Ma… - Chemical Society Reviews, 2017 - pubs.rsc.org
Covalent modification of therapeutic compounds is a clinically proven strategy to devise
prodrugs with enhanced treatment efficacies. This prodrug strategy relies on the modified …
prodrugs with enhanced treatment efficacies. This prodrug strategy relies on the modified …
RAFT polymerization to form stimuli-responsive polymers
G Moad - Polymer Chemistry, 2017 - pubs.rsc.org
Stimuli-responsive polymers adapt to their surrounding environment. These polymers are
capable of responding to a variety of external stimuli, which include optical, electrical …
capable of responding to a variety of external stimuli, which include optical, electrical …