Inflammation and aging: signaling pathways and intervention therapies
Aging is characterized by systemic chronic inflammation, which is accompanied by cellular
senescence, immunosenescence, organ dysfunction, and age-related diseases. Given the …
senescence, immunosenescence, organ dysfunction, and age-related diseases. Given the …
Cellular senescence: a key therapeutic target in aging and diseases
Cellular senescence is a hallmark of aging defined by stable exit from the cell cycle in
response to cellular damage and stress. Senescent cells (SnCs) can develop a …
response to cellular damage and stress. Senescent cells (SnCs) can develop a …
Immunosenescence, aging and successful aging
Y Wang, C Dong, Y Han, Z Gu, C Sun - Frontiers in immunology, 2022 - frontiersin.org
Aging induces a series of immune related changes, which is called immunosenescence,
playing important roles in many age-related diseases, especially neurodegenerative …
playing important roles in many age-related diseases, especially neurodegenerative …
Cellular senescence: from mechanisms to current biomarkers and senotherapies
V Lucas, C Cavadas, CA Aveleira, V Hook - Pharmacological Reviews, 2023 - Elsevier
An increase in life expectancy in developed countries has led to a surge of chronic aging-
related diseases. In the last few decades, several studies have provided evidence of the …
related diseases. In the last few decades, several studies have provided evidence of the …
Comorbidities and increased mortality of COVID-19 among the elderly: A systematic review
Purpose The purpose of current review is to conduct a systematic overview of articles
published between 2019 and 2021 on the relationship of comorbidities and mortality due to …
published between 2019 and 2021 on the relationship of comorbidities and mortality due to …
Effect of peripheral cellular senescence on brain aging and cognitive decline
V Budamagunta, A Kumar, A Rani, L Bean… - Aging …, 2023 - Wiley Online Library
We examine similar and differential effects of two senolytic treatments, ABT‐263 and
dasatinib+ quercetin (D+ Q), in preserving cognition, markers of peripheral senescence, and …
dasatinib+ quercetin (D+ Q), in preserving cognition, markers of peripheral senescence, and …
cGAS-STING pathway as a potential trigger of immunosenescence and inflammaging
CRR Schmitz, RM Maurmann, FTCR Guma… - Frontiers in …, 2023 - frontiersin.org
Aging is associated with an increased incidence of autoimmune diseases, despite the
progressive decline of immune responses (immunosenescence). This apparent paradox can …
progressive decline of immune responses (immunosenescence). This apparent paradox can …
Aging-related cellular, structural and functional changes in the lymph nodes: A significant component of immunosenescence? An overview
M Cakala-Jakimowicz, P Kolodziej-Wojnar… - Cells, 2021 - mdpi.com
Aging affects all tissues and organs. Aging of the immune system results in the severe
disruption of its functions, leading to an increased susceptibility to infections, an increase in …
disruption of its functions, leading to an increased susceptibility to infections, an increase in …
Cellular senescence: Neither irreversible nor reversible
M Reimann, S Lee, CA Schmitt - Journal of Experimental Medicine, 2024 - rupress.org
Cellular senescence is a critical stress response program implicated in embryonic
development, wound healing, aging, and immunity, and it backs up apoptosis as an ultimate …
development, wound healing, aging, and immunity, and it backs up apoptosis as an ultimate …
Senescent T cells: Beneficial and detrimental roles
P Laphanuwat, DCO Gomes… - Immunological Reviews, 2023 - Wiley Online Library
As the thymus involutes during aging, the T‐cell pool has to be maintained by the periodic
expansion of preexisting T cells during adulthood. A conundrum is that repeated episodes of …
expansion of preexisting T cells during adulthood. A conundrum is that repeated episodes of …