Oncogenic enhancers in leukemia
R Mulet-Lazaro, R Delwel - Blood Cancer Discovery, 2024 - aacrjournals.org
Although the study of leukemogenesis has traditionally focused on protein-coding genes,
the role of enhancer dysregulation is becoming increasingly recognized. The advent of high …
the role of enhancer dysregulation is becoming increasingly recognized. The advent of high …
Etiology of super-enhancer reprogramming and activation in cancer
RW Zhou, RE Parsons - Epigenetics & Chromatin, 2023 - Springer
Super-enhancers are large, densely concentrated swaths of enhancers that regulate genes
critical for cell identity. Tumorigenesis is accompanied by changes in the super-enhancer …
critical for cell identity. Tumorigenesis is accompanied by changes in the super-enhancer …
The leukemic oncogene EVI1 hijacks a MYC super-enhancer by CTCF-facilitated loops
S Ottema, R Mulet-Lazaro… - Nature …, 2021 - nature.com
Chromosomal rearrangements are a frequent cause of oncogene deregulation in human
malignancies. Overexpression of EVI1 is found in a subgroup of acute myeloid leukemia …
malignancies. Overexpression of EVI1 is found in a subgroup of acute myeloid leukemia …
Enhancer coamplification and hijacking promote oncogene expression in liposarcoma
Liposarcoma (LPS) is the most common soft-tissue sarcoma in adults with two major
subtypes, well differentiated and dedifferentiated. Both subtypes are characterized with the …
subtypes, well differentiated and dedifferentiated. Both subtypes are characterized with the …
MYB exhibits racially disparate expression, clinicopathologic association, and predictive potential for biochemical recurrence in prostate cancer
MYB acts as a potentiator of aggressiveness and castration resistance in prostate cancer
(PCa) through aberrant activation of androgen receptor (AR) signaling. Since Black men …
(PCa) through aberrant activation of androgen receptor (AR) signaling. Since Black men …
Structural variation cooperates with permissive chromatin to control enhancer hijacking–mediated oncogenic transcription
Structural variants (SVs) involving enhancer hijacking can rewire chromatin topologies to
cause oncogene activation in human cancers, including hematologic malignancies; …
cause oncogene activation in human cancers, including hematologic malignancies; …
EVI1 drives leukemogenesis through aberrant ERG activation
J Schmoellerl, IAM Barbosa, M Minnich, F Andersch… - Blood, 2023 - ashpublications.org
Chromosomal rearrangements involving the MDS1 and EVI1 complex locus (MECOM) on
chromosome 3q26 define an aggressive subtype of acute myeloid leukemia (AML) that is …
chromosome 3q26 define an aggressive subtype of acute myeloid leukemia (AML) that is …
Screening of ETO2-GLIS2–induced Super Enhancers identifies targetable cooperative dependencies in acute megakaryoblastic leukemia
Super Enhancers (SEs) are clusters of regulatory elements associated with cell identity and
disease. However, whether these elements are induced by oncogenes and can regulate …
disease. However, whether these elements are induced by oncogenes and can regulate …
A novel GATA2 distal enhancer mutation results in MonoMAC syndrome in 2 second cousins
RR West, TR Bauer Jr, LM Tuschong… - Blood …, 2023 - ashpublications.org
Mutations in the transcription factor GATA2 can cause MonoMAC syndrome, a GATA2
deficiency disease characterized by several findings, including disseminated …
deficiency disease characterized by several findings, including disseminated …
Oncogene EVI1 drives acute myeloid leukemia via a targetable interaction with CTBP2
D Pastoors, M Havermans, R Mulet-Lazaro, D Brian… - Science …, 2024 - science.org
Acute myeloid leukemia (AML) driven by the activation of EVI1 due to chromosome
3q26/MECOM rearrangements is incurable. Because transcription factors such as EVI1 are …
3q26/MECOM rearrangements is incurable. Because transcription factors such as EVI1 are …