Matters of the heart: Cellular sex differences
Nearly all cardiovascular diseases show sexual dimorphisms in prevalence, presentation,
and outcomes. Until recently, most clinical trials were carried out in males, and many animal …
and outcomes. Until recently, most clinical trials were carried out in males, and many animal …
Single cell genomics as a transformative approach for aquaculture research and innovation
Single cell genomics encompasses a suite of rapidly maturing technologies that measure
the molecular profiles of individual cells within target samples. These approaches provide a …
the molecular profiles of individual cells within target samples. These approaches provide a …
Characterising sex differences of autosomal DNA methylation in whole blood using the Illumina EPIC array
Background Sex differences are known to play a role in disease aetiology, progression and
outcome. Previous studies have revealed autosomal epigenetic differences between males …
outcome. Previous studies have revealed autosomal epigenetic differences between males …
[HTML][HTML] Sex differences in islet stress responses support female β cell resilience
GP Brownrigg, YH ** mouse brain is associated with neurodevelopmental functions and neurological phenotypes
Background Sex differences pose a challenge and an opportunity in biomedical research.
Understanding how sex chromosomes and hormones affect disease-causing mechanisms …
Understanding how sex chromosomes and hormones affect disease-causing mechanisms …
Sex-biased gene expression and gene-regulatory networks of sex-biased adverse event drug targets and drug metabolism genes
Background Previous pharmacovigilance studies and a retroactive review of cancer clinical
trial studies identified that women were more likely to experience drug adverse events (ie …
trial studies identified that women were more likely to experience drug adverse events (ie …
[HTML][HTML] Machine learning based analysis of single-cell data reveals evidence of subject-specific single-cell gene expression profiles in acute myeloid leukaemia …
A Chrysostomou, C Furlan, E Saccenti - Biochimica et Biophysica Acta …, 2024 - Elsevier
Abstract Acute Myeloid Leukaemia (AML) is characterized by uncontrolled growth of
immature myeloid cells, disrupting normal blood production. Treatment typically involves …
immature myeloid cells, disrupting normal blood production. Treatment typically involves …