Amelogenesis imperfecta (AI) represents a group of developmental conditions, genomic in
origin, which affect the structure and clinical appearance of enamel of all or nearly all the …

Dental anomalies are caused by complex interactions between genetic, epigenetic and
environmental factors during the long process of dental development. This process is …

Chondrocytes and osteoblasts differentiated from induced pluripotent stem cells (iPSCs) will
provide insights into skeletal development and genetic skeletal disorders and will generate …

Distal-less is the earliest known gene specifically expressed in develo** insect limbs; its
expression is maintained throughout limb development. The homeodomain transcription …

Bone and cartilage and their disorders are addressed under the following headings:
functions of bone; normal and abnormal bone remodeling; osteopetrosis and osteoporosis; …

Amelogenesis imperfecta (AI) is a heterogeneous group of genetic rare diseases disrupting
enamel development (Smith et al., Front Physiol, 2017a, 8, 333). The clinical enamel …

The head is anatomically the most sophisticated part of the body and its evolution was
fundamental to the origin of vertebrates; understanding its development is a formidable …

Dental enamel is the epithelial-derived hard tissue covering the crowns of teeth. It is the
most highly mineralized and hardest tissue in the body. Dental enamel is acellular and has …

Organs have to develop at precisely determined sites to ensure functionality of the whole
organism. Organogenesis is typically regulated by a series of interactions between …

We report the generation and analysis of mice homozygous for a targeted deletion of the
Dlx5 homeobox gene. Dlx5 mutant mice have multiple defects in craniofacial structures …