Most neurodegenerative disorders are diseases of protein homeostasis, with misfolded
aggregates accumulating. The neurodegenerative process is mediated by numerous …

Gallstone disease is one of the most prevalent gastrointestinal diseases with a substantial
burden to health care systems that is supposed to increase in ageing populations at risk …

Background: Ursodeoxycholic acid is increasingly being used for the treatment of chronic
cholestatic liver diseases. It appears to be generally well tolerated, but a systematic review …

Many patients with gallstones can be managed expectantly. Generally, only persons with
symptoms related to the presence of gallstones (eg, steady, nonparoxysmal pain lasting four …

Background Symptomatic cholelithiasis is a common surgical disease and accounts for half
of the over one million cholecystectomies performed in the USA annually. Despite its …

Background/Aims Ursodeoxycholic acid (UDCA) is the only well-established and widely
used agent for dissolving gallstones. Epidemiological and animal studies have suggested …

Background Symptomatic gallstones are common. Ursodeoxycholic acid (UDCA) is a bile
acid that dissolves gallstones. There is increasing interest in UDCA for symptomatic …

Context: Development of gallstones (GS) is reported during the use of somatostatin analogs
(SA) that are at present the mainstay for the medical treatment of acromegaly. Objective: To …

Chenodeoxycholic acid (CDCA), a primary bile acid (BA), has been demonstrated to play an
important role as a signaling molecule in various physiological functions. However, the role …

The goal of this paper is to describe the various manifestations of cholelithiasis, its workup,
and ultimately treatment. Cholecystectomy is the most common general surgery operation …