The c-Jun N-terminal kinase (JNKs), also known as stress-activated protein kinase (SAPK),
is one such family of multifunctional-signaling molecules, activated in response to wide …

Type 2 diabetes and depression are regarded as comorbid conditions, and three possible
directions of the association between the diseases can underlie this observation of …

Objective: Use of antidepressants has been reported to cause considerable weight gain.
The aim of this study was to assess the risk of diabetes mellitus associated with …

Background and Purpose The link between type 2 diabetes mellitus (T2DM) and depression
is bidirectional. However, the possibility that metabolic disorders may elicit anxiogenic …

Incomplete response to monoaminergic antidepressants in major depressive disorder
(MDD), and the phenomenon of neuroprogression, suggests a need for additional …

Mitochondrial impairment has been associated with the development of insulin resistance,
the hallmark of type 2 diabetes mellitus (T2DM). However, the relationship between …

IRS1 and IRS2 are key substrates of the insulin receptor tyrosine kinase. Mass spectrometry
reveals more than 50 phosphorylated IRS1 serine and threonine residues (Ser (P)/Thr (P) …

Aims/hypothesis The results of several studies have suggested a potential positive
association between use of antidepressant medication (ADM) and incident type 2 diabetes …

Abstract Type 2 diabetes (T2D) is a metabolic disease caused by the development of insulin
resistance (IR), relative insulin deficiency, and hyperglycemia. Hyperglycemia-induced …

Neurotransmitters and hormones regulate major immune functions, including the selection
of T helper (Th) 1 or Th2 cytokine responses, related to cell-mediated and humoral immunity …