Tetraspanins (Tspans) are a family of four-span transmembrane proteins, known as plasma
membrane “master organizers.” They form Tspan-enriched microdomains (TEMs or TERMs) …

The constitutive androstane receptor (CAR, NR1I3) plays a crucial role in the regulation of
drug metabolism, energy homeostasis, and cancer development through modulating the …

Divergence in the activity of biotransformation pathways could lead to species sensitivity
differences to chemical stress. To explore this hypothesis, we evaluated the …

Pregnane X receptor (PXR), constitutive androstane receptor (CAR), aryl hydrocarbon
receptor (AHR) and peroxisome proliferator‐activated receptor α (PPAR α) are ligand …

Polycyclic aromatic hydrocarbons (PAHs) are environmental pollutants produced by
incomplete combustion of organic matter. They induce their own metabolism by upregulating …

The nuclear receptor family member constitutive activated receptor (CAR) is activated by
structurally diverse drugs and environmentally-relevant chemicals leading to transcriptional …

During the last two decades, the constitutive androstane receptor (CAR; NR1I3) has
emerged as a master activator of drug-and xenobiotic-metabolizing enzymes and …

An endocrine-disrupting chemical Bisphenol A (BPA) binds specifically to a nuclear receptor
(NR) named ERRγ. Although the importance of receptor-binding evaluation for human NRs …

High doses of sodium phenobarbital (NaPB), a constitutive androstane receptor (CAR)
activator, have been shown to produce hepatocellular tumors in rodents by a mitogenic …

Structural and functional studies have provided numerous insights over the past years on
how members of the nuclear hormone receptor superfamily tightly regulate the expression of …