Several neurodevelopmental and neuropsychiatric disorders are characterized by
intermittent episodes of pathological activity. Although genetic therapies offer the ability to …

In vitro neuronal models have become an important tool to study healthy and diseased
neuronal circuits. The growing interest of neuroscientists to explore the dynamics of …

Much development has been directed toward improving the performance and automation of
spike sorting. This continuous development, while essential, has contributed to an over …

Micro-electrode arrays (MEAs) are increasingly used to characterize neuronal network
activity of human induced pluripotent stem cell (hiPSC)-derived neurons. Despite their gain …

Neurons derived from human induced Pluripotent Stem Cells (hiPSCs) provide a promising
new tool for studying neurological disorders. In the past decade, many protocols for …

Kleefstra syndrome (KS) is a neurodevelopmental disorder caused by mutations in the
histone methyltransferase EHMT1. To study the impact of decreased EHMT1 function in …

Despite the extensive use of in-vitro models for neuroscientific investigations and
notwithstanding the growing field of network electrophysiology, all studies on cultured cells …

Nanoparticles (NPs) are increasingly used in biomedical applications, but the factors that
influence their interactions with living cells need to be elucidated. Here, we reveal the role of …

Drug-induced seizure liabilities produce significant compound attrition during drug
discovery. Currently available in vitro cytotoxicity assays cannot predict all toxicity …

Epilepsy, intellectual and cortical sensory deficits, and psychiatric manifestations are the
most frequent manifestations of mitochondrial diseases. How mitochondrial dysfunction …