A bidirectional relationship exists between hypertension and psychiatric disorders, including
unipolar and bipolar depression, anxiety, post-traumatic stress disorder (PTSD), psychosis …

Introduction Develo** novel antipsychotic mechanisms of action and repurposing
established compounds for the treatment of schizophrenia is of utmost importance to …

Schizophrenia is a common mental disorder affecting patients' thoughts, behavior, and
cognition. Recently, the NRG1/ErbB4 signaling pathway emerged as a candidate …

ERBB receptor tyrosine kinases are involved in development and diseases like cancer,
cardiovascular, neurodevelopmental, and mental disorders. Although existing drugs target …

In this study, we investigated the effect of neuregulin-1 (NRG1) on demyelination and
neurological function in an ischemic stroke model, and further explored its neuroprotective …

Cognitive deficits are a hallmark of schizophrenia, for which no convincing pharmacological
treatment option is currently available. Here, we tested spironolactone as a repurposed …

Background Quick symptomatic remission after the onset of psychotic symptoms is critical in
schizophrenia treatment, determining the subsequent disease course and recovery. In this …

Working memory (WM), a key component of cognitive functions, is often impaired in
psychiatric disorders such as schizophrenia. Through a genome-guided drug repurposing …

Drug discovery campaigns are hampered by substantial attrition rates largely due to a lack
of efficacy and safety reasons associated with candidate drugs. This is true in particular for …

Neuroinflammation has been proposed to impact symptomatology in patients with
schizophrenia spectrum disorders. While previous studies have shown equivocal effects of …