Learning to recognize and respond to potential threats is crucial for survival. Pavlovian
threat conditioning represents a key paradigm for investigating the neurobiological …

The endocannabinoid (eCB) system is one the most ubiquitous signaling systems of the
brain and offers a rich pharmacology including multiple druggable targets. Preclinical …

The therapeutic benefits of the current medications for patients with psychiatric disorders
contrast with a great variety of adverse effects. The endocannabinoid system (ECS) …

The endogenous cannabinoid (ECB) system is a small molecule lipid signalling system that
is involved in stress response activation and is associated with PTSD, but it is unclear …

Background: Dysregulation of the endocannabinoid (eCB) system is implicated in various
stress-related neuropsychiatric disorders (SRDs), including anxiety, depression, and post …

The endocannabinoid system is known to be involved in mechanisms relevant to PTSD
aetiology and maintenance, though this understanding is mostly based on animal models of …

On the basis of substantial preclinical evidence, the endogenous cannabinoid system has
been proposed to be closely involved in stress reactivity and extinction of fear. Existing …

The replicability of fear conditioning research has come under recent scrutiny, with
increasing acknowledgment that the use of differing materials and methods may lead to …

Abstract Background Posttraumatic Stress Disorder (PTSD) is commonly treated with
exposure-based cognitive therapies that are based on the principles of fear acquisition and …

Safety learning creates associations between conditional stimuli and the absence of threat.
Studies of human fear conditioning have accumulated evidence for the neural signatures of …