Acute respiratory distress syndrome: causes, pathophysiology, and phenotypes

LDJ Bos, LB Ware - The Lancet, 2022 - thelancet.com
Acute respiratory distress syndrome (ARDS) is a common clinical syndrome of acute
respiratory failure as a result of diffuse lung inflammation and oedema. ARDS can be …

Acute respiratory distress syndrome in adults: diagnosis, outcomes, long-term sequelae, and management

EA Gorman, CM O'Kane, DF McAuley - The Lancet, 2022 - thelancet.com
Acute respiratory distress syndrome (ARDS) is characterised by acute hypoxaemic
respiratory failure with bilateral infiltrates on chest imaging, which is not fully explained by …

Simvastatin in critically ill patients with Covid-19

REMAP-CAP Investigators - New England Journal of Medicine, 2023 - Mass Medical Soc
Background The efficacy of simvastatin in critically ill patients with coronavirus disease 2019
(Covid-19) is unclear. Methods In an ongoing international, multifactorial, adaptive platform …

Identifying molecular phenotypes in sepsis: an analysis of two prospective observational cohorts and secondary analysis of two randomised controlled trials

P Sinha, VE Kerchberger, A Willmore… - The Lancet …, 2023 - thelancet.com
Background In sepsis and acute respiratory distress syndrome (ARDS), heterogeneity has
contributed to difficulty identifying effective pharmacotherapies. In ARDS, two molecular …

Practitioner's guide to latent class analysis: methodological considerations and common pitfalls

P Sinha, CS Calfee, KL Delucchi - Critical care medicine, 2021 - journals.lww.com
Latent class analysis is a probabilistic modeling algorithm that allows clustering of data and
statistical inference. There has been a recent upsurge in the application of latent class …

In-hospital use of statins is associated with a reduced risk of mortality among individuals with COVID-19

XJ Zhang, JJ Qin, XU Cheng, L Shen, YC Zhao, Y Yuan… - Cell metabolism, 2020 - cell.com
Statins are lipid-lowering therapeutics with favorable anti-inflammatory profiles and have
been proposed as an adjunct therapy for COVID-19. However, statins may increase the risk …

Biological phenoty** in sepsis and acute respiratory distress syndrome

P Sinha, NJ Meyer, CS Calfee - Annual review of medicine, 2023 - annualreviews.org
Heterogeneity in sepsis and acute respiratory distress syndrome (ARDS) is increasingly
being recognized as one of the principal barriers to finding efficacious targeted therapies …

Personalized mechanical ventilation in acute respiratory distress syndrome

P Pelosi, L Ball, CSV Barbas, R Bellomo, KEA Burns… - Critical care, 2021 - Springer
A personalized mechanical ventilation approach for patients with adult respiratory distress
syndrome (ARDS) based on lung physiology and morphology, ARDS etiology, lung imaging …

COVID-19 for the cardiologist: basic virology, epidemiology, cardiac manifestations, and potential therapeutic strategies

D Atri, HK Siddiqi, JP Lang, V Nauffal… - Basic to Translational …, 2020 - jacc.org
Summary Coronavirus disease-2019 (COVID-19), a contagious disease caused by severe
acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), has reached pandemic status. As …

Pathogenesis of acute respiratory distress syndrome

LA Huppert, MA Matthay… - Seminars in respiratory and …, 2019 - thieme-connect.com
Acute respiratory distress syndrome (ARDS) is a syndrome of acute respiratory failure
caused by noncardiogenic pulmonary edema. Despite five decades of basic and clinical …