[HTML][HTML] Advances in cancer therapy: A comprehensive review of CDK and EGFR inhibitors
M Hawash - Cells, 2024 - mdpi.com
Protein kinases have essential responsibilities in controlling several cellular processes, and
their abnormal regulation is strongly related to the development of cancer. The …
their abnormal regulation is strongly related to the development of cancer. The …
Identification of RdRp inhibitors against SARS-CoV-2 through E-pharmacophore-based virtual screening, molecular docking and MD simulations approaches
The outbreak of novel Coronavirus, an enduring pandemic declared by WHO, has
consequences to an alarming ongoing public health menace which has already claimed …
consequences to an alarming ongoing public health menace which has already claimed …
Synthesizes, characterization, molecular docking and in vitro bioactivity study of new compounds containing triple beta lactam rings
Penicillin bioactivity is continuously decreased due to the misuses by people which resulted
in an antibiotics resistance. However, B-lactam ring is still an effect group the attack bacterial …
in an antibiotics resistance. However, B-lactam ring is still an effect group the attack bacterial …
Medicinal significance of sp2/sp3 hybridized at C-3-substituted indole-containing lead molecules and FDA-approved drugs
Herein, the privilege in favor of biological importance of indole-containing scaffolds related
to the semi-synthetic and extracted from natural sources is summarized. Such compounds …
to the semi-synthetic and extracted from natural sources is summarized. Such compounds …
Identification of naphthyridine and quinoline derivatives as potential Nsp16-Nsp10 inhibitors: a pharmacoinformatics study
This research is a recent effort to explore some new heterocyclic compounds as novel and
potential nonstructural protein-16-nonstructural protein-10 (Nsp16-Nsp10) inhibitors for the …
potential nonstructural protein-16-nonstructural protein-10 (Nsp16-Nsp10) inhibitors for the …
Pharmacoinformatics-based identification of transmembrane protease serine-2 inhibitors from Morus Alba as SARS-CoV-2 cell entry inhibitors
Abstract Transmembrane protease serine-2 (TMPRSS2) is a cell-surface protein expressed
by epithelial cells of specific tissues including those in the aerodigestive tract. It helps the …
by epithelial cells of specific tissues including those in the aerodigestive tract. It helps the …
Identification of potent food constituents as SARS-CoV-2 papain-like protease modulators through advanced pharmacoinformatics approaches
The current ongoing pandemic of COVID-19 urges immediate treatment measures for
controlling the highly contagious SARS-CoV-2 infections. The papain-like protease (PLpro) …
controlling the highly contagious SARS-CoV-2 infections. The papain-like protease (PLpro) …
Design, synthesis of antipyrine-based Schiff bases and investigation of their cholinesterase and carbonic anhydrase activities by in vitro and in silico approaches
In this study, a series of antipyrine-based Schiff bases (1–10) was designed, synthesized,
and evaluated as potential inhibitors of various metabolic enzymes, including …
and evaluated as potential inhibitors of various metabolic enzymes, including …
[PDF][PDF] Preparation, Characterization and Evaluation of Biological Activity and Study of Molecular Docking of Some New Thiazoli-dine Derivatives
In this work, equal moles of hydrazone base derivatives and thioglycolic acid react to form
pentacyclic thiazolidine derivatives with zinc chloride as a catalyst and using dioxane as a …
pentacyclic thiazolidine derivatives with zinc chloride as a catalyst and using dioxane as a …
The role of 4-thiazolidinone scaffold in targeting variable biomarkers and pathways involving cancer
Background: Cancer can be considered as a genetic as well as a metabolic disorder. The
current cancer treatment scenario looks like aggravating tumor cell metabolism, causing the …
current cancer treatment scenario looks like aggravating tumor cell metabolism, causing the …