HPV-associated oropharyngeal cancer: epidemiology, molecular biology and clinical management

M Lechner, J Liu, L Masterson, TR Fenton - Nature reviews Clinical …, 2022 - nature.com
Abstract Human papillomavirus (HPV)-positive (HPV+) oropharyngeal squamous cell
carcinoma (OPSCC) has one of the most rapidly increasing incidences of any cancer in high …

Consensuses, controversies, and future directions in treatment deintensification for human papillomavirus‐associated oropharyngeal cancer

JJ Kang, Y Yu, L Chen, K Zakeri… - CA: a cancer journal …, 2023 - Wiley Online Library
The most common cancer caused by human papillomavirus (HPV) infection in the United
States is oropharyngeal cancer (OPC), and its incidence has been rising since the turn of the …

Detection of occult recurrence using circulating tumor tissue modified viral HPV DNA among patients treated for HPV-driven oropharyngeal carcinoma

BM Berger, GJ Hanna, MR Posner, EM Genden… - Clinical Cancer …, 2022 - AACR
Purpose: Despite generally favorable outcomes, 15% to 25% of patients with human
papillomavirus (HPV)-driven oropharyngeal squamous cell carcinoma (OPSCC) will have …

Liquid BIOpsy for MiNimal RESidual DiSease Detection in Head and Neck Squamous Cell Carcinoma (LIONESS)—a personalised circulating tumour DNA analysis in …

S Flach, K Howarth, S Hackinger, C Pipinikas… - British Journal of …, 2022 - nature.com
Background Head and neck squamous cell carcinoma (HNSCC) remain a substantial
burden to global health. Cell-free circulating tumour DNA (ctDNA) is an emerging biomarker …

Cell-free HPV DNA provides an accurate and rapid diagnosis of HPV-associated head and neck cancer

G Siravegna, CJ O'Boyle, S Varmeh, N Queenan… - Clinical Cancer …, 2022 - AACR
Purpose: HPV-associated head and neck squamous cell carcinoma (HPV+ HNSCC) is the
most common HPV-associated malignancy in the United States and continues to increase in …

[HTML][HTML] Prophylactic HPV vaccines in patients with HPV-associated diseases and cancer

M Reuschenbach, J Doorbar, M Del Pino, EA Joura… - Vaccine, 2023 - Elsevier
Individuals with human papillomavirus (HPV)-related disease remain at risk for subsequent
HPV infection and related disease after treatment of specific lesions. Prophylactic HPV …

Cell‐free human papillomavirus DNA kinetics after surgery for human papillomavirus–associated oropharyngeal cancer

CJ O'Boyle, G Siravegna, S Varmeh, N Queenan… - Cancer, 2022 - Wiley Online Library
Background New ultrasensitive methods for detecting residual disease after surgery are
needed in human papillomavirus–associated oropharyngeal squamous cell carcinoma …

Optimizing treatment de‐escalation in head and neck cancer: current and future perspectives

AJ Rosenberg, EE Vokes - The oncologist, 2021 - academic.oup.com
Abstract Treatment of locoregionally advanced head and neck squamous cell carcinoma
involves a multidisciplinary approach that combines surgery, radiotherapy, and systemic …

Early HPV ctDNA kinetics and imaging biomarkers predict therapeutic response in p16+ oropharyngeal squamous cell carcinoma

Y Cao, CT Haring, C Brummel, C Bhambhani… - Clinical Cancer …, 2022 - AACR
Purpose: In locally advanced p16+ oropharyngeal squamous cell carcinoma (OPSCC),(i) to
investigate kinetics of human papillomavirus (HPV) circulating tumor DNA (ctDNA) and …

Phase II multi-institutional clinical trial result of concurrent cetuximab and nivolumab in recurrent and/or metastatic head and neck squamous cell carcinoma

CH Chung, J Li, CE Steuer, P Bhateja, M Johnson… - Clinical Cancer …, 2022 - AACR
Purpose: A phase II multi-institutional clinical trial was conducted to determine overall
survival (OS) in patients with recurrent and/or metastatic (R/M) head and neck squamous …