RTS, S/AS01 vaccine (Mosquirix™): an overview

MB Laurens - Human vaccines & immunotherapeutics, 2020 - Taylor & Francis
Malaria is an illness caused by Plasmodium parasites transmitted to humans by infected
mosquitoes. Of the five species that infect humans, P. falciparum exacts the highest toll in …

[HTML][HTML] Mosquirix™ RTS, S/AS01 vaccine development, immunogenicity, and efficacy

AY Nadeem, A Shehzad, SU Islam, EA Al-Suhaimi… - Vaccines, 2022 - mdpi.com
Malaria is a parasitic infection caused by bites from Plasmodium falciparum (P. falciparum)-
infected mosquitoes with a present scale of symptoms ranging from moderate fever to …

Map** functional humoral correlates of protection against malaria challenge following RTS, S/AS01 vaccination

TJ Suscovich, JK Fallon, J Das, AR Demas… - Science Translational …, 2020 - science.org
Vaccine development has the potential to be accelerated by coupling tools such as systems
immunology analyses and controlled human infection models to define the protective …

Host-parasite interactions during Plasmodium infection: Implications for immunotherapies

P Chandley, R Ranjan, S Kumar, S Rohatgi - Frontiers in Immunology, 2023 - frontiersin.org
Malaria is a global infectious disease that remains a leading cause of morbidity and mortality
in the develo** world. Multiple environmental and host and parasite factors govern the …

The road to elimination: current state of schistosomiasis research and progress towards the end game

P Ogongo, RK Nyakundi, GK Chege… - Frontiers in …, 2022 - frontiersin.org
The new WHO Roadmap for Neglected Tropical Diseases targets the global elimination of
schistosomiasis as a public health problem. To date, control strategies have focused on …

[HTML][HTML] Plasmodium falciparum Malaria Vaccines and Vaccine Adjuvants

SR Bonam, L Rénia, G Tadepalli, J Bayry, HMS Kumar - Vaccines, 2021 - mdpi.com
Malaria—a parasite vector-borne disease—is a global health problem, and Plasmodium
falciparum has proven to be the deadliest among Plasmodium spp., which causes malaria in …

Mature beyond their years: young children who escape detection of parasitemia despite living in settings of intense malaria transmission

P Holla, J Bhardwaj, TM Tran - Biochemical Society …, 2024 - portlandpress.com
Despite having the highest risk of progressing to severe disease due to lack of acquired
immunity, the youngest children living in areas of highly intense malaria transmission have …

[HTML][HTML] Non-neutralizing functions in anti-SARS-CoV-2 IgG antibodies

S Reinig, SR Shih - Biomedical Journal, 2024 - Elsevier
Most individuals infected with or vaccinated against COVID-19 develop antigenic
neutralizing immunoglobulin G (IgG) antibodies against the SARS-CoV-2 spike protein …

IgG and IgM responses to the Plasmodium falciparum asexual stage antigens reflect respectively protection against malaria during pregnancy and infanthood

MLE Gbaguidi, R Adamou, S Edslev, A Hansen… - Malaria Journal, 2024 - Springer
Background Plasmodium falciparum malaria is a public health issue mostly seen in tropical
countries. Until now, there is no effective malaria vaccine against antigens specific to the …

B‐cell memory in malaria: Myths and realities

D Pérez‐Mazliah, FM Ndungu, R Aye… - Immunological …, 2020 - Wiley Online Library
B‐cell and antibody responses to Plasmodium spp., the parasite that causes malaria, are
critical for control of parasitemia and associated immunopathology. Antibodies also provide …