Since determination of the myoglobin structure in 1957, X-ray crystallography, as the
anchoring tool of structural biology, has played an instrumental role in deciphering the …

Proline-rich regions (PRRs) of proteins occur widely in both prokaryotes and eukaryotes.
They are frequently found as multiple tandem repeats, often of considerable length. Despite …

The sensitivity of the commonly used progressive multiple sequence alignment method has
been greatly improved for the alignment of divergent protein sequences. Firstly, individual …

Multivalent biopolymers phase separate into membrane-less organelles (MLOs) which
exhibit liquid-like behavior. Here, we explore formation of prototypical MOs from multivalent …

Background Microcell-mediated transfer of chromosome 6 into human C8161 and MelJuSo
melanoma cells suppresses their ability to metastasize by at least 95% without affecting their …

Directed movement is a characteristic of many living organisms and occurs as a result of the
transformation of chemical energy into mechanical energy. Myosin is one of three families of …

Structure-based and physics-based coarse-grained molecular force fields have become
attractive approaches to gain mechanistic insight into the function of large biomolecular …

The function and activity of a protein are often modulated by other proteins with which it
interacts. This review is intended as a practical guide to the analysis of such protein-protein …

Src family kinases are prototypical modular signaling proteins. Their conserved domain
organization includes a myristoylated N-terminal segment followed by SH3, SH2, and …

X-ray or NMR structures of proteins are often derived without their ligands, and even when
the structure of a full complex is available, the area of contact that is functionally and …