Lysosomal nanotoxicity: Impact of nanomedicines on lysosomal function

M Uzhytchak, B Smolková, M Lunova, A Frtús… - Advanced Drug Delivery …, 2023 - Elsevier
Although several nanomedicines got clinical approval over the past two decades, the clinical
translation rate is relatively small so far. There are many post-surveillance withdrawals of …

Nucleic acid nanostructures for in vivo applications: The influence of morphology on biological fate

NI Langlois, KY Ma, HA Clark - Applied Physics Reviews, 2023 - pubs.aip.org
The development of programmable biomaterials for use in nanofabrication represents a
major advance for the future of biomedicine and diagnostics. Recent advances in structural …

DNA nanopores as artificial membrane channels for bioprotonics

L Luo, S Manda, Y Park, B Demir, J Sanchez… - Nature …, 2023 - nature.com
Biological membrane channels mediate information exchange between cells and facilitate
molecular recognition. While tuning the shape and function of membrane channels for …

Tunable multivalent aptamer-based DNA nanostructures to regulate multiheteroreceptor-mediated tumor recognition

X Hu, H Chi, X Fu, J Chen, L Dong… - Journal of the …, 2024 - ACS Publications
Precise map** and regulation of cell surface receptors hold immense significance in
disease treatment, such as cancer, infection, and neurodisorders, but also face enormous …

Self-Assembly of Ultrasmall 3D Architectures of (l)-Acyclic Threoninol Nucleic Acids with High Thermal and Serum Stability

MK Skaanning, J Bønnelykke… - Journal of the …, 2024 - ACS Publications
The primary challenge of implementing DNA nanostructures in biomedical applications lies
in their vulnerability to nuclease degradation and variations in ionic strength. Furthermore …

Entropy-driven three-dimensional DNA nanofireworks for simultaneous real-time imaging of telomerase and MicroRNA in living cells

J Wang, K Wang, H Peng, Z Zhang, Z Yang… - Analytical …, 2023 - ACS Publications
Real-time monitoring of different types of intracellular tumor-related biomarkers is of key
importance for the identification of tumor cells. However, it is hampered by the low …

Hapten-decorated DNA nanostructures decipher the antigen-mediated spatial organization of antibodies involved in mast cell activation

L Schneider, KS Rabe, CM Domínguez… - ACS nano, 2023 - ACS Publications
The immunological response of mast cells is controlled by the multivalent binding of
antigens to immunoglobulin E (IgE) antibodies bound to the high-affinity receptor FcεRI on …

Peptide-coated DNA nanostructures as a platform for control of lysosomal function in cells

P Elblová, M Lunova, SJW Henry, X Tu, A Calé… - Chemical Engineering …, 2024 - Elsevier
DNA nanotechnology is a rapidly growing field that provides exciting tools for biomedical
applications. Targeting lysosomal functions with nanomaterials, such as DNA …

Surface-patterned DNA origami rulers reveal nanoscale distance dependency of the epidermal growth factor receptor activation

I Mayer, T Karimian, K Gordiyenko, A Angelin… - Nano Letters, 2024 - ACS Publications
The nanoscale arrangement of ligands can have a major effect on the activation of
membrane receptor proteins and thus cellular communication mechanisms. Here we report …

Impact of mechanical cues on key cell functions and cell-nanoparticle interactions

P Elblová, M Lunova, A Dejneka, M Jirsa, O Lunov - Discover Nano, 2024 - Springer
In recent years, it has been recognized that mechanical forces play an important regulative
role in living organisms and possess a direct impact on crucial cell functions, ranging from …