Lysosomal nanotoxicity: Impact of nanomedicines on lysosomal function
Although several nanomedicines got clinical approval over the past two decades, the clinical
translation rate is relatively small so far. There are many post-surveillance withdrawals of …
translation rate is relatively small so far. There are many post-surveillance withdrawals of …
Nucleic acid nanostructures for in vivo applications: The influence of morphology on biological fate
The development of programmable biomaterials for use in nanofabrication represents a
major advance for the future of biomedicine and diagnostics. Recent advances in structural …
major advance for the future of biomedicine and diagnostics. Recent advances in structural …
DNA nanopores as artificial membrane channels for bioprotonics
Biological membrane channels mediate information exchange between cells and facilitate
molecular recognition. While tuning the shape and function of membrane channels for …
molecular recognition. While tuning the shape and function of membrane channels for …
Tunable multivalent aptamer-based DNA nanostructures to regulate multiheteroreceptor-mediated tumor recognition
X Hu, H Chi, X Fu, J Chen, L Dong… - Journal of the …, 2024 - ACS Publications
Precise map** and regulation of cell surface receptors hold immense significance in
disease treatment, such as cancer, infection, and neurodisorders, but also face enormous …
disease treatment, such as cancer, infection, and neurodisorders, but also face enormous …
Self-Assembly of Ultrasmall 3D Architectures of (l)-Acyclic Threoninol Nucleic Acids with High Thermal and Serum Stability
MK Skaanning, J Bønnelykke… - Journal of the …, 2024 - ACS Publications
The primary challenge of implementing DNA nanostructures in biomedical applications lies
in their vulnerability to nuclease degradation and variations in ionic strength. Furthermore …
in their vulnerability to nuclease degradation and variations in ionic strength. Furthermore …
Entropy-driven three-dimensional DNA nanofireworks for simultaneous real-time imaging of telomerase and MicroRNA in living cells
Real-time monitoring of different types of intracellular tumor-related biomarkers is of key
importance for the identification of tumor cells. However, it is hampered by the low …
importance for the identification of tumor cells. However, it is hampered by the low …
Hapten-decorated DNA nanostructures decipher the antigen-mediated spatial organization of antibodies involved in mast cell activation
The immunological response of mast cells is controlled by the multivalent binding of
antigens to immunoglobulin E (IgE) antibodies bound to the high-affinity receptor FcεRI on …
antigens to immunoglobulin E (IgE) antibodies bound to the high-affinity receptor FcεRI on …
Peptide-coated DNA nanostructures as a platform for control of lysosomal function in cells
DNA nanotechnology is a rapidly growing field that provides exciting tools for biomedical
applications. Targeting lysosomal functions with nanomaterials, such as DNA …
applications. Targeting lysosomal functions with nanomaterials, such as DNA …
Surface-patterned DNA origami rulers reveal nanoscale distance dependency of the epidermal growth factor receptor activation
I Mayer, T Karimian, K Gordiyenko, A Angelin… - Nano Letters, 2024 - ACS Publications
The nanoscale arrangement of ligands can have a major effect on the activation of
membrane receptor proteins and thus cellular communication mechanisms. Here we report …
membrane receptor proteins and thus cellular communication mechanisms. Here we report …
Impact of mechanical cues on key cell functions and cell-nanoparticle interactions
In recent years, it has been recognized that mechanical forces play an important regulative
role in living organisms and possess a direct impact on crucial cell functions, ranging from …
role in living organisms and possess a direct impact on crucial cell functions, ranging from …