The complementary value of intraoperative fluorescence imaging and Raman spectroscopy for cancer surgery: combining the incompatibles

LJ Lauwerends, H Abbasi, TC Bakker Schut… - European Journal of …, 2022 - Springer
A clear margin is an important prognostic factor for most solid tumours treated by surgery.
Intraoperative fluorescence imaging using exogenous tumour-specific fluorescent agents …

Selective-sampling Raman imaging techniques for ex vivo assessment of surgical margins in cancer surgery

MG Lizio, R Boitor, I Notingher - Analyst, 2021 - pubs.rsc.org
One of the main challenges in cancer surgery is to ensure the complete excision of the
tumour while sparing as much healthy tissue as possible. Histopathology, the gold-standard …

Dynamic sparse sampling for confocal raman microscopy

S Zhang, Z Song, GMDP Godaliyadda, DH Ye… - Analytical …, 2018 - ACS Publications
The total number of data points required for image generation in Raman microscopy was
greatly reduced using sparse sampling strategies, in which the preceding set of …

Nonlinear optical characterization of pharmaceutical formulations

AM Sherman, N Takanti, J Rong, GJ Simpson - TrAC Trends in Analytical …, 2021 - Elsevier
Unique challenges in formulating the next generation of active pharmaceutical ingredients
(APIs) into stable formulations demand analytical tools not currently available using common …

Kinetic modeling of accelerated stability testing enabled by second harmonic generation microscopy

Z Song, S Sarkar, AD Vogt, GD Danzer… - Analytical …, 2018 - ACS Publications
The low limits of detection afforded by second harmonic generation (SHG) microscopy
coupled with image analysis algorithms enabled quantitative modeling of the temperature …

In situ crystal growth rate distributions of active pharmaceutical ingredients

S Sarkar, Z Song, SR Griffin, N Takanti… - Molecular …, 2019 - ACS Publications
Single-particle tracking of crystal growth performed in situ enables substantial improvements
in the signal-to-noise ratio (SNR) for recovered crystal nucleation and growth rates by …

Spectroscopic Methods in Solid‐state Characterization

C Strachan, J Saarinen, T Lipiäinen… - Characterization of …, 2021 - Wiley Online Library
This chapter describes the principles and applications of spectroscopic methods used to
probe solid‐state structure of particulates. The methods include mid‐infrared, near‐infrared …

Demonstration of the hierarchical arrangement of persistent luminescent microparticles in direct do**-prepared photonic glasses using second-harmonic generation …

S Annurakshita, V Lahti, L Petit… - Optical Materials Express, 2022 - opg.optica.org
Using three-dimensional (3D) second-harmonic generation (SHG) scanning microscopy, we
unravel the formation and distribution of distinct and highly localized persistent luminescent …

Solubility Measurement of the Crystal Form 1 and Form 4 Nirmatrelvir in Six Mono-Solvents and Two Binary Solvent Mixtures

J Sun, Y Wu, X Wang, J Lin, Y Liu - Journal of Chemical & …, 2023 - ACS Publications
Nirmatrelvir (NMT) is an orally administered severe acute respiratory syndrome coronavirus
2 main protease inhibitor with several crystal forms, including form 1 and form 4. In this work …

[HTML][HTML] Polymorphism in S (+) Clopidogrel-Picrate: Insights from X-ray Diffraction, Vibrational Spectroscopy, Thermal Analysis, and Quantum Chemistry

A Cvetkovski, P Makreski, L Pejov… - Crystals, 2023 - mdpi.com
The crystal structures of two pseudopolymorphic forms of S (+) clopidogrel–picrate are
reported. Form 1 crystallizes in the monoclinic space group P 21 with an ionic couple S (+) …