Eosinophils are usually considered as end‐stage degranulating effector cells of innate
immunity. However, accumulating evidence has revealed additional roles for eosinophils …

The mammalian target of rapamycin (mTOR) integrates nutrient and mitogen signals to
regulate cell growth (increased cell mass and cell size) and cell division. The …

While certain members of ubiquitin-coupled enzymes (E2s) have garnered attention as
potential therapeutic targets across diverse diseases, research progress on Ubiquitin …

Transcription factor GATA binding protein 2 (GATA2) plays critical roles in hematopoietic
stem cell survival and proliferation, granulocyte–monocyte progenitor differentiation, and …

Summary Interferon (IFN)‐λ1 [interleukin (IL)‐29] is a member of the interferon lambda family
(also known as type III interferons), whose members are distantly related to both the type I …

Tumor specific Th9 cells are potential effector cells for adoptive therapy of human cancers.
TNF family members OX40L, TL1A and GITRL have been shown to promote the induction of …

Inflammation is a central feature of asthma and chronic obstructive pulmonary disease
(COPD). Despite recent advances in the knowledge of the pathogenesis of asthma and …

Abstract Interleukin 5 (IL-5) plays crucial roles in type 2-high asthma by mediating eosinophil
maturation, activation, chemotaxis and survival. Inhibition of IL-5 signaling is considered a …

Eosinophils are major effector cells during allergic responses and helminth infections.
Recent studies further highlight eosinophils as important players in many other biological …

Introduction Asthma is driven by an inflammatory response against normally harmless
environmental inorganic and organic compounds in the respiratory tract. Immune responses …