The heat shock protein 90 (HSP90) chaperone machinery is a key regulator of proteostasis
under both physiological and stress conditions in eukaryotic cells. As HSP90 has several …

The endoplasmic reticulum (ER) is a fascinating network of tubules through which secretory
and transmembrane proteins enter unfolded and exit as either folded or misfolded proteins …

The accumulation of misfolded proteins in the human brain is one of the critical features of
many neurodegenerative diseases, including Alzheimer's disease (AD). Assembles of beta …

The prion glycoprotein (PrPC) is mostly located at the cell surface, tethered to the plasma
membrane through a glycosyl-phosphatydil inositol (GPI) anchor. Misfolding of PrPC is …

Abstract Hop/Stip1/Sti1 is thought to be essential as a co-chaperone to facilitate substrate
transfer between the Hsp70 and Hsp90 molecular chaperones. Despite this proposed key …

Tissue pH is an indicator of altered cellular metabolism in diseases including stroke and
cancer. Ischemic tissue often becomes acidic due to increased anaerobic respiration …

Abstract The Hsp70 and Hsp90 molecular chaperone systems are critical regulators of
protein homeostasis (proteostasis) in eukaryotes under normal and stressed conditions. The …

Extracellular vesicles (EVs) are important means of intercellular communication and a potent
tool for regenerative therapy. In ischaemic stroke, transient blockage of a brain artery leads …

Maternal autoantibody-related ASD (MAR ASD) is a subtype of autism in which pathogenic
maternal autoantibodies (IgG) cross the placenta, access the develo** brain, and cause …

Heart activity and long-term function are regulated by the sympathetic and parasympathetic
branches of the nervous system. Parasympathetic neurons have received increased …