Voltage-gated calcium channels are required for many key functions in the body. In this
review, the different subtypes of voltage-gated calcium channels are described and their …

Voltage-gated calcium channels are the primary mediators of depolarization-induced
calcium entry into neurons. There is great diversity of calcium channel subtypes due to …

Voltage-gated calcium channels are important regulators of brain, heart and muscle
functions, and their dysfunction can give rise to pathophysiological conditions ranging from …

Opioids are the oldest and most potent drugs for the treatment of severe pain. Their clinical
application is undisputed in acute (eg, postoperative) and cancer pain, but their long-term …

Dopamine signalling modes differ in kinetics and spatial patterns of receptor activation,. How
these modes contribute to motor function, motivation and learning has long been …

The detection and processing of painful stimuli in afferent sensory neurons is critically
dependent on a wide range of different types of voltage-and ligand-gated ion channels …

Voltage-gated calcium (Ca 2+) channels initiate release of neurotransmitters at synapses,
and regulation of presynaptic Ca 2+ channels has a powerful influence on synaptic strength …

Calcium regulates a wide spectrum of physiological processes such as heartbeat, muscle
contraction, neuronal communication, hormone release, cell division, and gene …

Voltage gated calcium channels (Ca2+ channels) are key mediators of depolarization
induced calcium influx into excitable cells, and thereby play pivotal roles in a wide array of …

Background and Purpose Cannabinoids are a promising therapeutic avenue for chronic
pain. However, clinical trials often fail to report analgesic efficacy of cannabinoids. Inhibition …