Lung cancer is the leading cause of cancer-related death across the world. Unlike lung
adenocarcinoma, patients with lung squamous cell carcinoma (LSCC) have not benefitted …

Progress in strategies aimed at breaking down therapeutic target proteins has led to a
paradigm shift in drug discovery. Thalidomide and its derivatives are the only protein …

Despite several decades of intense research focused on understanding function (s) and
disease-associated malfunction of p53, there is no sign of any “mid-life crisis” in this rapidly …

Purpose Androgenetic alopecia, commonly known as male pattern baldness, is the most
common type of progressive hair loss disorder in men. The aim of this paper is to review …

The mammary gland is a highly dynamic organ that undergoes profound changes within its
epithelium during puberty and the reproductive cycle. These changes are fueled by …

Functional modeling of many adult epithelia is limited by the difficulty in maintaining relevant
stem cell populations in culture. Here, we show that dual inhibition of SMAD signaling …

The mammary epithelium is highly responsive to local and systemic signals, which
orchestrate morphogenesis of the ductal tree during puberty and pregnancy. Based on …

Abstract p53 functions as a transcription factor involved in cell-cycle control, DNA repair,
apoptosis and cellular stress responses. However, besides inducing cell growth arrest and …

Despite many reports of putative stem-cell-based treatments in genetic and degenerative
disorders or severe injuries, the number of proven stem cell therapies has remained small …

Abstract Signal Transducer and Activator of Transcription 3 (STAT3) is a transcription factor
with many important functions in the biology of normal and transformed cells. Its regulation is …