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Inflammation, Aging, and Cardiovascular Disease: JACC Review Topic of the Week
Aging and inflammation both contribute pivotally to cardiovascular (CV) and cerebrovascular
disease, the leading causes of death and disability worldwide. The concept of inflamm-aging …
disease, the leading causes of death and disability worldwide. The concept of inflamm-aging …
Targeting innate immunity-driven inflammation in CKD and cardiovascular disease
Mortality among patients with chronic kidney disease (CKD) is largely a consequence of
cardiovascular disease (CVD) and is a particular concern given the increasing prevalence of …
cardiovascular disease (CVD) and is a particular concern given the increasing prevalence of …
TP53-mediated clonal hematopoiesis confers increased risk for incident atherosclerotic disease
Somatic mutations in blood indicative of clonal hematopoiesis of indeterminate potential
(CHIP) are associated with an increased risk of hematologic malignancy, coronary artery …
(CHIP) are associated with an increased risk of hematologic malignancy, coronary artery …
Clonal hematopoiesis of indeterminate potential predicts adverse outcomes in patients with atherosclerotic cardiovascular disease
Background Clonal hematopoiesis of indeterminate potential (CHIP)—the age-related clonal
expansion of blood stem cells with leukemia-associated mutations—is a novel …
expansion of blood stem cells with leukemia-associated mutations—is a novel …
Heart failure promotes multimorbidity through innate immune memory
Y Nakayama, K Fujiu, T Oshima, J Matsuda… - Science …, 2024 - science.org
Patients with heart failure (HF) often experience repeated acute decompensation and
develop comorbidities such as chronic kidney disease and frailty syndrome. Although this …
develop comorbidities such as chronic kidney disease and frailty syndrome. Although this …
Unidirectional association of clonal hematopoiesis with atherosclerosis development
Clonal hematopoiesis, a condition in which acquired somatic mutations in hematopoietic
stem cells lead to the outgrowth of a mutant hematopoietic clone, is associated with a higher …
stem cells lead to the outgrowth of a mutant hematopoietic clone, is associated with a higher …
Clonal hematopoiesis, somatic mosaicism, and age-associated disease
Somatic mosaicism, the occurrence of multiple genetically distinct cell clones within the
same tissue, is an evitable consequence of human aging. The hematopoietic system is no …
same tissue, is an evitable consequence of human aging. The hematopoietic system is no …
Clonal hematopoiesis and its impact on human health
Aging is associated with increased mutational burden in every tissue studied. Occasionally,
fitness-increasing mutations will arise, leading to stem cell clonal expansion. This process …
fitness-increasing mutations will arise, leading to stem cell clonal expansion. This process …
Associations of clonal hematopoiesis with recurrent vascular events and death in patients with incident ischemic stroke
Clonal hematopoiesis (CH) is common among older people and is associated with an
increased risk of atherosclerosis, inflammation, and shorter overall survival. Age and …
increased risk of atherosclerosis, inflammation, and shorter overall survival. Age and …
Association of clonal hematopoiesis of indeterminate potential with worse kidney function and anemia in two cohorts of patients with advanced chronic kidney disease
Background Clonal hematopoiesis of indeterminate potential (CHIP) is an inflammatory
premalignant disorder resulting from acquired genetic mutations in hematopoietic stem cells …
premalignant disorder resulting from acquired genetic mutations in hematopoietic stem cells …