GM-CSF: A double-edged sword in cancer immunotherapy

A Kumar, A Taghi Khani, A Sanchez Ortiz… - Frontiers in …, 2022 - frontiersin.org
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a cytokine that drives the
generation of myeloid cell subsets including neutrophils, monocytes, macrophages, and …

[HTML][HTML] Therapeutic targeting of angiogenesis molecular pathways in angiogenesis-dependent diseases

A Fallah, A Sadeghinia, H Kahroba, A Samadi… - Biomedicine & …, 2019 - Elsevier
Angiogenesis is a critical step in the progression of almost all human malignancies and
some other life-threatening diseases. Anti-angiogenic therapy is a novel and effective …

Macrophages: an inflammatory link between angiogenesis and lymphangiogenesis

BA Corliss, MS Azimi, JM Munson, SM Peirce… - …, 2016 - Wiley Online Library
Angiogenesis and lymphangiogenesis often occur in response to tissue injury or in the
presence of pathology (eg, cancer), and it is these types of environments in which …

Macrophages: a review of their role in wound healing and their therapeutic use

RJ Snyder, J Lantis, RS Kirsner, V Shah… - Wound Repair and …, 2016 - Wiley Online Library
Macrophages are mononuclear phagocytes established during embryogenesis and derived
from the yolk sac or the fetal liver but also recruited from the blood and bone marrow under …

Reactive oxygen species and NOX enzymes are emerging as key players in cutaneous wound repair

D André-Lévigne, A Modarressi, MS Pepper… - International journal of …, 2017 - mdpi.com
Our understanding of the role of oxygen in cell physiology has evolved from its long-
recognized importance as an essential factor in oxidative metabolism to its recognition as an …

Mesenchymal stem/stromal cell therapy in blood–brain barrier preservation following ischemia: Molecular mechanisms and prospects

PT Do, CC Wu, YH Chiang, CJ Hu… - International journal of …, 2021 - mdpi.com
Ischemic stroke is the leading cause of mortality and long-term disability worldwide.
Disruption of the blood–brain barrier (BBB) is a prominent pathophysiological mechanism …

VCAM-1+ placenta chorionic villi-derived mesenchymal stem cells display potent pro-angiogenic activity

W Du, X Li, Y Chi, F Ma, Z Li, S Yang, B Song… - Stem cell research & …, 2016 - Springer
Abstract Introduction Mesenchymal stem cells (MSCs) represent a heterogeneous cell
population that is promising for regenerative medicine. The present study was designed to …

Dual gene‐activated dermal scaffolds regulate angiogenesis and wound healing by mediating the coexpression of VEGF and angiopoietin‐1

T Weng, M Yang, W Zhang, R **, S **a… - Bioengineering & …, 2023 - Wiley Online Library
The vascularization of dermal substitutes is a key challenge in efforts to heal deep skin
defects. In this study, dual gene‐activated dermal scaffolds (DGADSs‐1) were fabricated by …

The senescence-associated secretory phenotype: Fueling a wound that never heals

T Pulido, MC Velarde, F Alimirah - Mechanisms of Ageing and …, 2021 - Elsevier
Wound healing is impaired with advanced age and certain chronic conditions, such as
diabetes and obesity. Moreover, common cancer treatments, including chemotherapy and …

[HTML][HTML] Loss of TRPV2-mediated blood flow autoregulation recapitulates diabetic retinopathy in rats

M O'Hare, G Esquiva, MK McGahon… - JCI insight, 2022 - ncbi.nlm.nih.gov
Loss of retinal blood flow autoregulation is an early feature of diabetes that precedes the
development of clinically recognizable diabetic retinopathy (DR). Retinal blood flow …