Highlights•Single-particle cryoEM facilitates structural determination of membrane proteins
without the need of crystallization.•Advances in membrane protein sample preparation are …

Membrane proteins remain a somewhat enigmatic group of biomolecules. On the one hand
they mediate some of the most important processes in biology with molecular mechanisms …

Membrane proteins are difficult to work with due to their insolubility in aqueous solution and
quite often their poor stability in detergent micelles. Here, we present the peptidisc for their …

Amphipathic styrene-maleic acid (SMA) copolymers directly solubilize biomembranes into
SMA-lipid particles, or SMALPs, that are often regarded as nanodiscs and hailed as a native …

Amphipathic copolymers such as poly (styrene-maleic acid)(SMA) are promising tools for the
facile extraction of membrane proteins (MPs) into native nanodiscs. Here, we designed and …

Amphiphilic copolymers capable of extracting membrane proteins directly from lipid bilayers
into" native nanodiscs" promise a simpler membrane protein sample preparation procedure …

Polymer stabilized nanodiscs are self-assembled structures composed of a polymer belt that
wraps around a segment of lipid bilayer, and as such are capable of encapsulating …

The concept of a memtein as the minimal unit of membrane function is proposed here, and
refers to the complex of a membrane protein together with a continuous layer of biological …

Membrane proteins can be reconstituted in polymer-encased nanodiscs for studies under
near-physiological conditions and in the absence of detergents, but traditional styrene …

Native lipid bilayer mimetics, including those that use amphiphilic polymers, are important
for the effective study of membrane-bound peptides and proteins. Copolymers of vinyl ether …