Protein–Protein interactions (PPIs) are involved in a myriad of cellular processes in all living
organisms and the modulation of PPIs is already under investigation for the development of …

Staphylococcus aureus is a common human commensal pathogen that causes a wide range
of infectious diseases. Due to the generation of antimicrobial resistance, the pathogen …

Functionalized aryl sulfonamides are important building blocks in the pharmaceutical
industry. A one-step synthesis catalyzed by a copper salt was developed using stable solid …

A Chan–Lam-type C–S coupling reaction using sodium aryl sulfinates has been developed
to provide diaryl thioethers in up to 92% yields in the presence of a copper catalyst and …

The increasing prevalence of multidrug-resistant pathogens necessitates the urgent
development of new antimicrobial agents with innovative modes of action for the next …

Formation of a bacterial RNA polymerase (RNAP) holoenzyme by a catalytic core RNAP and
a sigma (σ) initiation factor is essential for bacterial viability. As the primary binding site for …

RNA polymerase is an essential enzyme involved in bacterial transcription, playing a crucial
role in RNA synthesis. However, it requires the association with sigma factors to initiate this …

Transcription is an essential biological process in bacteria requiring a core enzyme, RNA
polymerase (RNAP). Bacterial RNAP is catalytically active but requires sigma (σ) factors for …

A scalable catalytic synthesis method using commodity chemicals for constructing diaryl
thioethers directly from sodium arylsulfinates and iodoarenes is reported in this study. In the …

Bacterial RNA polymerase (RNAP), the core enzyme responsible for bacterial transcription,
requires the NusG factor for efficient transcription elongation and termination. As the primary …