Advances in macrocyclic chelators for positron emission tomography imaging
M Li, S Wang, Q Kong, X Cheng, H Yan, Y **ng, X Lan… - View, 2023 - Wiley Online Library
In recent years, radiometals have been successfully applied to medicine because of their
breadth of decay properties and increased production and availability. Bifunctional chelators …
breadth of decay properties and increased production and availability. Bifunctional chelators …
Amphiphilic distyrylbenzene derivatives as potential therapeutic and imaging agents for soluble and insoluble amyloid β aggregates in Alzheimer's disease
Alzheimer's Disease (AD) is the most common neurodegenerative disease, and efficient
therapeutic and early diagnostic agents for AD are still lacking. Herein, we report the …
therapeutic and early diagnostic agents for AD are still lacking. Herein, we report the …
Is less more? Influence of the coordination geometry of Copper (II) picolinate chelate complexes on metabolic stability
A growing number of copper (II) complexes have been identified as suitable candidates for
biomedical applications. Here, we show that the biocompatibility and stability of copper (II) …
biomedical applications. Here, we show that the biocompatibility and stability of copper (II) …
Copper Coordination Chemistry of Sulfur Pendant Cyclen Derivatives: An Attempt to Hinder the Reductive-Induced Demetalation in 64/67Cu Radiopharmaceuticals
The Cu2+ complexes formed by a series of cyclen derivatives bearing sulfur pendant arms,
1, 4, 7, 10-tetrakis [2-(methylsulfanyl) ethyl]-1, 4, 7, 10-tetraazacyclododecane (DO4S), 1, 4 …
1, 4, 7, 10-tetrakis [2-(methylsulfanyl) ethyl]-1, 4, 7, 10-tetraazacyclododecane (DO4S), 1, 4 …
Dye-surfactant co-assembly as the chromogenic indicator for nanomolar level detection of Cu (I) ions via a color-changing response
Polyaromatic amphiphilic probes have been developed, that can be involved in
chromogenic detection of Cu+ ions in anionic micelles. A rapid change in solution color from …
chromogenic detection of Cu+ ions in anionic micelles. A rapid change in solution color from …
When ring makes the difference: coordination properties of Cu 2+/Cu+ complexes with sulfur-pendant polyazamacrocycles for radiopharmaceutical applications
M Tosato, M Pelosato, S Franchi, AA Isse… - New Journal of …, 2022 - pubs.rsc.org
Three polyazamacrocyclic ligands, ie 1, 5, 9-tris [2-(methylsulfanyl) ethyl]-1, 5, 9-
triazacyclododecane (TACD3S), 1, 4, 7, 10-tetrakis [2-(methylsulfanyl) ethyl]-1, 4, 7, 10 …
triazacyclododecane (TACD3S), 1, 4, 7, 10-tetrakis [2-(methylsulfanyl) ethyl]-1, 4, 7, 10 …
Neutral Ligands as Potential 64Cu Chelators for Positron Emission Tomography Imaging Applications in Alzheimer's Disease
Positron emission tomography (PET), which uses positron-emitting radionuclides to
visualize and measure processes in the human body, is a useful noninvasive diagnostic tool …
visualize and measure processes in the human body, is a useful noninvasive diagnostic tool …
Radiometal Complexes as Pharmacokinetic Modifiers: A Potent 68Ga-Labeled Gastrin-Releasing Peptide Receptor Antagonist Based on the Macrocyclic Metal …
MV Schreck, C Burgard, A Schmidtke… - Molecular …, 2023 - ACS Publications
The gastrin-releasing peptide receptor (GRPr) is overexpressed in various cancer types
including prostate and breast carcinomas, making it an attractive target for molecular …
including prostate and breast carcinomas, making it an attractive target for molecular …
[HTML][HTML] On the dissociation pathways of copper complexes relevant as PET imaging agents
R Uzal-Varela, V Patinec, R Tripier, L Valencia… - Journal of Inorganic …, 2022 - Elsevier
Several bifunctional chelators have been synthesized in the last years for the development
of new 64 Cu-based PET agents for in vivo imaging. When designing a metal-based PET …
of new 64 Cu-based PET agents for in vivo imaging. When designing a metal-based PET …
HNODThia: A Promising Chelator for the Development of 64Cu Radiopharmaceuticals
Herein, we present the synthesis and coordination chemistry of copper (II) and zinc (II)
complexes of two novel heterocyclic triazacyclononane (tacn)-based chelators (H NODThia …
complexes of two novel heterocyclic triazacyclononane (tacn)-based chelators (H NODThia …