The mucus clearance system is the dominant mechanical host defense system of the human
lung. Mucus is cleared from the lung by cilia and airflow, including both two-phase gas-liquid …

Muco-Obstructive Lung Diseases This review covers the normal mechanisms of mucus
formation and how they are abnormal in common conditions—such as COPD, cystic fibrosis …

Colonization of the intestine by oral microbes has been linked to multiple diseases such as
inflammatory bowel disease and colon cancer, yet mechanisms allowing expansion in this …

Bronchiectasis, a progressive chronic airway disease, is characterized by microbial
colonization and infection. We present an approach to the multi-biome that integrates …

ABSTRACT The expanded Human Oral Microbiome Database (eHOMD) is a
comprehensive microbiome database for sites along the human aerodigestive tract that …

Amplicon-based marker gene surveys form the basis of most microbiome and other
microbial community studies. Such PCR-based methods have multiple steps, each of which …

Background Chronic airway inflammation is the main driver of pathogenesis in respiratory
diseases such as severe asthma, chronic obstructive pulmonary disease, cystic fibrosis (CF) …

The lungs are not sterile or free from bacteria; rather, they harbor a distinct microbiome
whose composition is driven by different ecological rules than for the gastrointestinal tract …

Background The airways of patients with cystic fibrosis (CF) are highly complex, subject to
various environmental conditions as well as a distinct microbiota. Pseudomonas aeruginosa …

The human microbiota is fundamental to correct immune system development and balance.
Dysbiosis, or microbial content alteration in the gut and respiratory tract, is associated with …