[HTML][HTML] Process, material, and regulatory considerations for 3D printed medical devices and tissue constructs

WL Ng, J An, CK Chua - Engineering, 2024 - Elsevier
Abstract Three-dimensional (3D) printing is a highly automated platform that facilitates
material deposition in a layer-by-layer approach to fabricate pre-defined 3D complex …

Materials strategies to overcome the foreign body response

X Zhou, Y Wang, J Ji, P Zhang - Advanced Healthcare …, 2024 - Wiley Online Library
The foreign body response (FBR) is an immune‐mediated reaction that can occur with most
biomaterials and biomedical devices. The FBR initiates a deterioration in the performance of …

Decoding the “fingerprint” of implant materials: insights into the foreign body reaction

Y Chen, Z Luo, W Meng, K Liu, Q Chen, Y Cai, Z Ding… - Small, 2024 - Wiley Online Library
Foreign body reaction (FBR) is a prevalent yet often overlooked pathological phenomenon,
particularly within the field of biomedical implantation. The presence of FBR poses a heavy …

Probing nanotopography-mediated macrophage polarization via integrated machine learning and combinatorial biophysical cue map**

Y Hou, B Conklin, HK Choi, L Yang, KB Lee - ACS nano, 2024 - ACS Publications
Inflammatory responses, leading to fibrosis and potential host rejection, significantly hinder
the long-term success and widespread adoption of biomedical implants. The ability to …

[HTML][HTML] Latest advances: improving the anti-inflammatory and immunomodulatory properties of PEEK materials

Z Zhang, X Zhang, Z Zheng, J **n, S Han, J Qi… - Materials Today Bio, 2023 - Elsevier
Excellent biocompatibility, mechanical properties, chemical stability, and elastic modulus
close to bone tissue make polyetheretherketone (PEEK) a promising orthopedic implant …

Immunocompatible elastomer with increased resistance to the foreign body response

X Zhou, Z Lu, W Cao, Z Zhu, Y Chen, Y Ni, Z Liu… - Nature …, 2024 - nature.com
Polymeric elastomers are extensively employed to fabricate implantable medical devices.
However, implantation of the elastomers can induce a strong immune rejection known as the …

Releasable, Immune‐Instructive, Bioinspired Multilayer Coating Resists Implant‐Induced Fibrosis while Accelerating Tissue Repair

R Toita, M Kitamura, A Tsuchiya… - Advanced …, 2024 - Wiley Online Library
Implantable biomaterials trigger foreign body reactions (FBRs), which reduces the functional
life of medical devices and prevents effective tissue regeneration. Although existing …

Solution Blow Spun Poly (ethylene oxide)/Poly-ε-caprolactone System: Properties and Dissolution in Water

M Lorente, G González-Gaitano, M Valero… - ACS Applied Polymer …, 2023 - ACS Publications
In the present work, fibrous materials based on poly (ethylene oxide)(PEO), poly-ε-
caprolactone (PCL), and a mixture of them (PEO/PCL) have been prepared by solution blow …

Cell dynamics and metabolism of the foreign body response: characterizing host-biomaterial interactions for next-generation medical implant biocompatibility

N Callaghan, CA Rempe, Z Froom, K Medd… - Materials …, 2024 - pubs.rsc.org
Implantable medical devices (IMDs) collectively represent a critical mainstay in modern
medicine. Used in many chronic diseases and in acute surgical interventions, IMDs are often …

[HTML][HTML] Bacterial nanocellulose as a simple and tailorable platform for controlled drug release

L Costa, AF Carvalho, AJS Fernandes… - International Journal of …, 2024 - Elsevier
In this study we present a proof of concept of a simple and straightforward approach for the
development of a Bacterial Nanocellulose drug delivery system (BNC-DDS), envisioning the …