Targeting PI3K in cancer: mechanisms and advances in clinical trials
Abstract Phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR)
signaling is one of the most important intracellular pathways, which can be considered as a …
signaling is one of the most important intracellular pathways, which can be considered as a …
PI3K inhibitors in cancer: clinical implications and adverse effects
The phospatidylinositol-3 kinase (PI3K) pathway is a crucial intracellular signaling pathway
which is mutated or amplified in a wide variety of cancers including breast, gastric, ovarian …
which is mutated or amplified in a wide variety of cancers including breast, gastric, ovarian …
Regulation of breast cancer metastasis signaling by miRNAs
Despite the decline in death rate from breast cancer and recent advances in targeted
therapies and combinations for the treatment of metastatic disease, metastatic breast cancer …
therapies and combinations for the treatment of metastatic disease, metastatic breast cancer …
Akt-targeted therapy as a promising strategy to overcome drug resistance in breast cancer–A comprehensive review from chemotherapy to immunotherapy
Breast cancer is the most frequently occurring cancer in women. Chemotherapy in
combination with immunotherapy has been used to treat breast cancer. Atezolizumab …
combination with immunotherapy has been used to treat breast cancer. Atezolizumab …
Immunomodulatory properties of PI3K/AKT/mTOR and MAPK/MEK/ERK inhibition augment response to immune checkpoint blockade in melanoma and triple-negative …
Hyperactivation of PI3K/AKT/mTOR and MAPK/MEK/ERK signaling pathways is commonly
observed in many cancers, including triple-negative breast cancer (TNBC) and melanoma …
observed in many cancers, including triple-negative breast cancer (TNBC) and melanoma …
Targeting DNA double-strand break repair pathways to improve radiotherapy response
M Toulany - Genes, 2019 - mdpi.com
More than half of cancer patients receive radiotherapy as a part of their cancer treatment.
DNA double-strand breaks (DSBs) are considered as the most lethal form of DNA damage …
DNA double-strand breaks (DSBs) are considered as the most lethal form of DNA damage …
Skp2 in the ubiquitin‐proteasome system: a comprehensive review
MD Asmamaw, Y Liu, YC Zheng… - Medicinal Research …, 2020 - Wiley Online Library
The ubiquitin‐proteasome system (UPS) is a complex process that regulates protein stability
and activity by the sequential actions of E1, E2 and E3 enzymes to influence diverse aspects …
and activity by the sequential actions of E1, E2 and E3 enzymes to influence diverse aspects …
Targeting metabolism to overcome cancer drug resistance: A promising therapeutic strategy for diffuse large B cell lymphoma
M Pi, H Kuang, C Yue, Q Yang, A Wu, Y Li… - Drug Resistance …, 2022 - Elsevier
Cancer cell metabolism including aerobic glycolysis, amino acid and fatty acid metabolism,
has been extensively studied. Metabolic reprogramming is a major hallmark of cancer …
has been extensively studied. Metabolic reprogramming is a major hallmark of cancer …
Targeting feedback activation of signaling transduction pathways to overcome drug resistance in cancer
X Wang, W Jiang, Y Du, D Zhu, J Zhang, C Fang… - Drug Resistance …, 2022 - Elsevier
Dysregulation or aberrant signaling transduction contributes to tumorigenesis. Targeting
these abnormal signaling pathways becomes an effective anticancer strategy. However …
these abnormal signaling pathways becomes an effective anticancer strategy. However …
Mechanisms of resistance to PI3K inhibitors in cancer: adaptive responses, drug tolerance and cellular plasticity
Simple Summary The phosphoinositide-3-kinase (PI3K) pathway is the most frequently
activated pathway in human cancers. Consequently, a number of compounds targeting the …
activated pathway in human cancers. Consequently, a number of compounds targeting the …