Oligodendrocytes: Myelination, plasticity, and axonal support

M Simons, EM Gibson, KA Nave - Cold Spring Harbor …, 2024 - cshperspectives.cshlp.org
The myelination of axons has evolved to enable fast and efficient transduction of electrical
signals in the vertebrate nervous system. Acting as an electric insulator, the myelin sheath is …

Structure and neural mechanisms of catatonia

S Walther, K Stegmayer, JE Wilson… - The Lancet Psychiatry, 2019 - thelancet.com
Catatonia is a psychomotor syndrome associated with several psychiatric and medical
conditions. Psychomotor signs range from stupor to agitation, and include pathognomonic …

Myelin dysfunction drives amyloid-β deposition in models of Alzheimer's disease

C Depp, T Sun, AO Sasmita, L Spieth, SA Berghoff… - Nature, 2023 - nature.com
The incidence of Alzheimer's disease (AD), the leading cause of dementia, increases rapidly
with age, but why age constitutes the main risk factor is still poorly understood. Brain ageing …

[HTML][HTML] Targeted complement inhibition at synapses prevents microglial synaptic engulfment and synapse loss in demyelinating disease

S Werneburg, J Jung, RB Kunjamma, SK Ha… - Immunity, 2020 - cell.com
Multiple sclerosis (MS) is a demyelinating, autoimmune disease of the central nervous
system. While work has focused on myelin and axon loss in MS, less is known about …

[HTML][HTML] Methotrexate chemotherapy induces persistent tri-glial dysregulation that underlies chemotherapy-related cognitive impairment

EM Gibson, S Nagaraja, A Ocampo, LT Tam, LS Wood… - Cell, 2019 - cell.com
Chemotherapy results in a frequent yet poorly understood syndrome of long-term
neurological deficits. Neural precursor cell dysfunction and white matter dysfunction are …

Noteworthy perspectives on microglia in neuropsychiatric disorders

H Zhu, A Guan, J Liu, L Peng, Z Zhang… - Journal of …, 2023 - Springer
Microglia are so versatile that they not only provide immune surveillance for central nervous
system, but participate in neural circuitry development, brain blood vessels formation, blood …

Catatonia

S Heckers, S Walther - New England Journal of Medicine, 2023 - Mass Medical Soc
Catatonia | New England Journal of Medicine Skip to main content The New England Journal of
Medicine homepage Advanced Search SEARCH SPECIALTIES Cardiology Clinical Medicine …

Activated microglia drive demyelination via CSF1R signaling

DE Marzan, V Brügger‐Verdon, BL West, S Liddelow… - Glia, 2021 - Wiley Online Library
Microgliosis is a prominent pathological feature in many neurological diseases including
multiple sclerosis (MS), a progressive auto‐immune demyelinating disorder. The precise …

Catatonia and the immune system: a review

JP Rogers, TA Pollak, G Blackman… - The Lancet Psychiatry, 2019 - thelancet.com
Catatonia is a psychomotor disorder featuring stupor, posturing, and echophenomena. This
Series paper examines the evidence for immune dysregulation in catatonia. Activation of the …

[HTML][HTML] Catatonia: clinical overview of the diagnosis, treatment, and clinical challenges

AN Edinoff, SE Kaufman, JW Hollier, CG Virgen… - Neurology …, 2021 - mdpi.com
Catatonia is a syndrome that has been associated with several mental illness disorders but
that has also presented as a result of other medical conditions. Schizophrenia and other …