The development of new ion-activation/dissociation methods continues to be one of the most
active areas of mass spectrometry owing to the broad applications of tandem mass …

According to Genome Sequencing Project statistics (http://www. ncbi. nlm. nih.
gov/genomes/static/gpstat. html), as of February 16, 2012, complete gene sequences have …

Peptide‐centered shotgun analysis of proteins has been the core technology in mass
spectrometry based proteomics and has enabled numerous biological discoveries, such as …

Beside gene expression and translational control, which are relatively slow, PTM of proteins
represents the major level of regulation, from very fast and reversible to slow or irreversible …

Several proteomics approaches are available that are defined by the level (protein or
peptide) at which analysis takes place. The most widely applied method still is bottom-up …

The analysis of peptides and proteins as well as the grander scope of proteomics (large
scale study of proteins) has been advanced by the development of a versatile array of ion …

The latest advances in the study of the reactivity of metal-oxo clusters toward proteins
showcase how fundamental insights obtained so far open new opportunities in …

This tutorial review describes the principles and practices of electron capture and transfer
dissociation (ECD/ETD or ExD) mass spectrometry (MS) employed for peptide and protein …

Mass spectrometry (MS)-based proteomics workflows can crudely be classified into two
distinct regimes, targeting either relatively small peptides (ie, 0.7 kDa< M w< 3.0 kDa) or …

Epigenetic regulation of gene expression is, at least in part, mediated by histone
modifications. PTMs of histones change chromatin structure and regulate gene transcription …