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Making the leap from technique to treatment—genetic engineering is paving the way for more efficient phage therapy
Bacteriophages (phages) are viruses specific to bacteria that target them with great
efficiency and specificity. Phages were first studied for their antibacterial potential in the …
efficiency and specificity. Phages were first studied for their antibacterial potential in the …
Evolvability costs of niche expansion
What prevents generalists from displacing specialists, despite obvious competitive
advantages of utilizing a broad niche? The classic genetic explanation is antagonistic …
advantages of utilizing a broad niche? The classic genetic explanation is antagonistic …
Competition-driven eco-evolutionary feedback reshapes bacteriophage lambda's fitness landscape and enables speciation
A major challenge in evolutionary biology is explaining how populations navigate rugged
fitness landscapes without getting trapped on local optima. One idea illustrated by adaptive …
fitness landscapes without getting trapped on local optima. One idea illustrated by adaptive …
Viruses in astrobiology
Viruses are the most abundant biological entities on Earth, and yet, they have not received
enough consideration in astrobiology. Viruses are also extraordinarily diverse, which is …
enough consideration in astrobiology. Viruses are also extraordinarily diverse, which is …
A trait-based approach to predicting viral host-range evolvability
Predicting the evolution of virus host range has proven to be extremely difficult, in part
because of the sheer diversity of viruses, each with unique biology and ecological …
because of the sheer diversity of viruses, each with unique biology and ecological …
[HTML][HTML] Variation profile of the orthotospovirus genome
Orthotospoviruses are plant-infecting members of the family Tospoviridae (order
Bunyavirales), have a broad host range and are vectored by polyphagous thrips in a …
Bunyavirales), have a broad host range and are vectored by polyphagous thrips in a …
Develo** an empirical model for spillover and emergence: Orsay virus host range in Caenorhabditis
A lack of tractable experimental systems in which to test hypotheses about the ecological
and evolutionary drivers of disease spillover and emergence has limited our understanding …
and evolutionary drivers of disease spillover and emergence has limited our understanding …
High parasite diversity maintained after an alga–virus coevolutionary arms race
Arms race dynamics are a common outcome of host–parasite coevolution. While they can
theoretically be maintained indefinitely, realistic arms races are expected to be finite. Once …
theoretically be maintained indefinitely, realistic arms races are expected to be finite. Once …
Experimental Evolution Studies in Φ6 Cystovirus
S Singhal, AK Balitactac, AG Nayagam… - Viruses, 2024 - mdpi.com
Experimental evolution studies, in which biological populations are evolved in a specific
environment over time, can address questions about the nature of spontaneous mutations …
environment over time, can address questions about the nature of spontaneous mutations …
Variable routes to genomic and host adaptation among coronaviruses
Natural selection operating on the genomes of viral pathogens in different host species
strongly contributes to adaptation facilitating host colonization. Here, we analyse, quantify …
strongly contributes to adaptation facilitating host colonization. Here, we analyse, quantify …