Next generation gold drugs and probes: chemistry and biomedical applications

RT Mertens, S Gukathasan, AS Arojojoye… - Chemical …, 2023 - ACS Publications
The gold drugs, gold sodium thiomalate (Myocrisin), aurothioglucose (Solganal), and the
orally administered auranofin (Ridaura), are utilized in modern medicine for the treatment of …

Mitochondria as a cellular hub in infection and inflammation

P Andrieux, C Chevillard, E Cunha-Neto… - International journal of …, 2021 - mdpi.com
Mitochondria are the energy center of the cell. They are found in the cell cytoplasm as
dynamic networks where they adapt energy production based on the cell's needs. They are …

Lysosomes as dynamic regulators of cell and organismal homeostasis

A Ballabio, JS Bonifacino - Nature reviews Molecular cell biology, 2020 - nature.com
Exciting new discoveries have transformed the view of the lysosome from a static organelle
dedicated to the disposal and recycling of cellular waste to a highly dynamic structure that …

A break in mitochondrial endosymbiosis as a basis for inflammatory diseases

MP Murphy, LAJ O'Neill - Nature, 2024 - nature.com
Mitochondria retain bacterial traits due to their endosymbiotic origin, but host cells do not
recognize them as foreign because the organelles are sequestered. However, the regulated …

Mitochondria-derived cell-to-cell communication

ZAA Dache, AR Thierry - Cell Reports, 2023 - cell.com
In addition to their intracellular mobility, mitochondria and their components can exist
outside the cells from which they originate. As a result, they are capable of acting on non …

Mitophagy in health and disease. Molecular mechanisms, regulatory pathways, and therapeutic implications

MS D'Arcy - Apoptosis, 2024 - Springer
Mitophagy, a specialised form of autophagy, selectively targeting damaged or dysfunctional
mitochondria, and is crucial for maintaining cellular homeostasis and mitochondrial quality …

[HTML][HTML] The role of taurine in mitochondria health: more than just an antioxidant

CJ Jong, P Sandal, SW Schaffer - Molecules, 2021 - mdpi.com
Taurine is a naturally occurring sulfur-containing amino acid that is found abundantly in
excitatory tissues, such as the heart, brain, retina and skeletal muscles. Taurine was first …

Emerging views of mitophagy in immunity and autoimmune diseases

Y Xu, J Shen, Z Ran - Autophagy, 2020 - Taylor & Francis
Mitophagy is a vital form of autophagy for selective removal of dysfunctional or redundant
mitochondria. Accumulating evidence implicates elimination of dysfunctional mitochondria …

Blood contains circulating cell‐free respiratory competent mitochondria

Z Al Amir Dache, A Otandault, R Tanos… - The FASEB …, 2020 - Wiley Online Library
Mitochondria are considered as the power‐generating units of the cell due to their key role
in energy metabolism and cell signaling. However, mitochondrial components could be …

[HTML][HTML] Efferocytosis fuels requirements of fatty acid oxidation and the electron transport chain to polarize macrophages for tissue repair

S Zhang, S Weinberg, M DeBerge, A Gainullina… - Cell metabolism, 2019 - cell.com
During wound injury, efferocytosis fills the macrophage with a metabolite load nearly equal
to the phagocyte itself. A timely question pertains to how metabolic phagocytic signaling …