Hypoalbuminemia is associated with inflammation. Despite being addressed repeatedly in
the literature, there is still confusion regarding its pathogenesis and clinical significance …

Antibodies are essential components of an adaptive immune response. Immunoglobulin G
(IgG) is the most common type of antibody found in circulation and extracellular fluids …

The effectiveness of a drug is dependent on accumulation at the site of action at therapeutic
levels, however, challenges such as rapid renal clearance, degradation or non-specific …

The purpose of making a “biobetter” biologic is to improve on the salient characteristics of a
known biologic for which there is, minimally, clinical proof of concept or, maximally …

Natural biomacromolecules have attracted increased attention as carriers in biomedicine in
recent years because of their inherent biochemical and biophysical properties including …

Introduction: Rapid clearance of drugs from the body results in short therapeutic half-life and
is an integral property of many protein and peptide-based drugs. To maintain the desired …

Peptides and proteins are widely used to treat a range of medical conditions; however, they
often have to be injected and their effects are short-lived. These shortcomings of the native …

Beyond potency, a good developability profile is a key attribute of a biological drug.
Selecting and screening for such attributes early in the drug development process can save …

The neonatal Fc receptor (FcRn) was first found to be responsible for transporting antibodies
of the immunoglobulin G (IgG) class from the mother to the fetus or neonate as well as for …

Therapeutic antibodies and antibody derivatives comprise the majority of today's
biotherapeutics. Routine methods to generate novel antibodies, such as immunization and …