Multi-omics profiling for health
The world has witnessed a steady rise in both non-infectious and infectious chronic
diseases, prompting a cross-disciplinary approach to understand and treating disease …
diseases, prompting a cross-disciplinary approach to understand and treating disease …
Genetics meets proteomics: perspectives for large population-based studies
Proteomic analysis of cells, tissues and body fluids has generated valuable insights into the
complex processes influencing human biology. Proteins represent intermediate phenotypes …
complex processes influencing human biology. Proteins represent intermediate phenotypes …
Genomic atlas of the proteome from brain, CSF and plasma prioritizes proteins implicated in neurological disorders
Understanding the tissue-specific genetic controls of protein levels is essential to uncover
mechanisms of post-transcriptional gene regulation. In this study, we generated a genomic …
mechanisms of post-transcriptional gene regulation. In this study, we generated a genomic …
Finding genetically-supported drug targets for Parkinson's disease using Mendelian randomization of the druggable genome
CS Storm, DA Kia, MM Almramhi… - Nature …, 2021 - nature.com
Parkinson's disease is a neurodegenerative movement disorder that currently has no
disease-modifying treatment, partly owing to inefficiencies in drug target identification and …
disease-modifying treatment, partly owing to inefficiencies in drug target identification and …
Map** the serum proteome to neurological diseases using whole genome sequencing
G Png, A Barysenka, L Repetto, P Navarro… - Nature …, 2021 - nature.com
Despite the increasing global burden of neurological disorders, there is a lack of effective
diagnostic and therapeutic biomarkers. Proteins are often dysregulated in disease and have …
diagnostic and therapeutic biomarkers. Proteins are often dysregulated in disease and have …
Next generation plasma proteome profiling to monitor health and disease
The need for precision medicine approaches to monitor health and disease makes it
important to develop sensitive and accurate assays for proteome profiles in blood. Here, we …
important to develop sensitive and accurate assays for proteome profiles in blood. Here, we …
Epigenetic scores for the circulating proteome as tools for disease prediction
Protein biomarkers have been identified across many age-related morbidities. However,
characterising epigenetic influences could further inform disease predictions. Here, we …
characterising epigenetic influences could further inform disease predictions. Here, we …
Eye-brain connections revealed by multimodal retinal and brain imaging genetics
The retina, an anatomical extension of the brain, forms physiological connections with the
visual cortex of the brain. Although retinal structures offer a unique opportunity to assess …
visual cortex of the brain. Although retinal structures offer a unique opportunity to assess …
[HTML][HTML] Proteome-wide Mendelian randomization identifies causal links between blood proteins and severe COVID-19
In November 2021, the COVID-19 pandemic death toll surpassed five million individuals. We
applied Mendelian randomization including> 3,000 blood proteins as exposures to identify …
applied Mendelian randomization including> 3,000 blood proteins as exposures to identify …
Multi-method genome-and epigenome-wide studies of inflammatory protein levels in healthy older adults
Background The molecular factors which control circulating levels of inflammatory proteins
are not well understood. Furthermore, association studies between molecular probes and …
are not well understood. Furthermore, association studies between molecular probes and …