Physics and biology of ultrahigh dose-rate (FLASH) radiotherapy: a topical review

N Esplen, MS Mendonca… - Physics in Medicine & …, 2020 - iopscience.iop.org
Ultrahigh dose-rate radiotherapy (RT), or'FLASH'therapy, has gained significant momentum
following various in vivo studies published since 2014 which have demonstrated a reduction …

The current status of preclinical proton FLASH radiation and future directions

ES Diffenderfer, BS Sørensen, A Mazal… - Medical …, 2022 - Wiley Online Library
We review the current status of proton FLASH experimental systems, including preclinical
physical and biological results. Technological limitations on preclinical investigation of …

Ultrahigh dose rate pencil beam scanning proton dosimetry using ion chambers and a calorimeter in support of first in‐human FLASH clinical trial

E Lee, AM Lourenço, J Speth, N Lee, A Subiel… - Medical …, 2022 - Wiley Online Library
Purpose To provide ultrahigh dose rate (UHDR) pencil beam scanning (PBS) proton
dosimetry comparison of clinically used plane‐parallel ion chambers, PTW (Physikalisch …

Clinical commissioning of intensity‐modulated proton therapy systems: report of AAPM Task Group 185

JB Farr, MF Moyers, CE Allgower, M Bues… - Medical …, 2021 - Wiley Online Library
Proton therapy is an expanding radiotherapy modality in the United States and worldwide.
With the number of proton therapy centers treating patients increasing, so does the need for …

Characterization of a high‐resolution 2D transmission ion chamber for independent validation of proton pencil beam scanning of conventional and FLASH dose …

W Zou, ES Diffenderfer, K Ota, P Boisseau… - Medical …, 2021 - Wiley Online Library
Introduction Ultra‐high dose rate (FLASH) radiotherapy has become a popular research
topic with the potential to reduce normal tissue toxicities without losing the benefit of tumor …

Adaptation and dosimetric commissioning of a synchrotron-based proton beamline for FLASH experiments

M Yang, X Wang, F Guan, U Titt, K Iga… - Physics in Medicine …, 2022 - iopscience.iop.org
Objective. Irradiation with ultra-high dose rates (> 40 Gy s− 1), also known as FLASH
irradiation, has the potential to shift the paradigm of radiation therapy because of its reduced …

Dose detectors, sensors, and their applications

S Giordanengo, H Palmans - Medical physics, 2018 - Wiley Online Library
This article is intended to present the different types of particle and radiation detectors
available for applications in particle therapy. Several types of detectors and sensors exist for …

Flash irradiation with proton beams: beam characteristics and their implications for beam diagnostics

KP Nesteruk, S Psoroulas - applied sciences, 2021 - mdpi.com
FLASH irradiations use dose-rates orders of magnitude higher than commonly used in
patient treatments. Such irradiations have shown interesting normal tissue sparing in cell …

Experimental determination of k Q factors for two types of ionization chambers in scanned proton beams

J Medin, P Andreo, H Palmans - Physics in Medicine & Biology, 2022 - iopscience.iop.org
Objective. Experimental determination of beam quality k Q factors for two types of Farmer
ionization chambers, NE2571 and IBA FC65-G, in a scanned proton beam for three nominal …

Characterization of 250 MeV protons from the Varian ProBeam PBS system for FLASH radiation therapy

S Charyyev, CW Chang, M Zhu, L Lin… - … Journal of Particle …, 2023 - meridian.allenpress.com
Shoot-through proton FLASH radiation therapy has been proposed where the highest
energy is extracted from a cyclotron to maximize the dose rate (DR). Although our proton …