The eukaryotic endomembrane system consists of multiple interconnected organelles. Rab
GTPases are organelle-specific markers that give identity to these membranes by recruiting …

The early endosome (EE), also known as the sorting endosome (SE) is a crucial station for
the sorting of cargoes, such as receptors and lipids, through the endocytic pathways. The …

Rab7 is a small GTPase that belongs to the Rab family and controls transport to late
endocytic compartments such as late endosomes and lysosomes. The mechanism of action …

Of the approximately 70 human Rab GTPases, nearly three-quarters are involved in
endocytic trafficking. Significant plasticity in endosomal membrane transport pathways is …

Several of the most important discoveries in the field of membrane traffic have come from
studies of Rab GTPases by Marino Zerial and Peter Novick and their colleagues. Zerial was …

The occurrence of nonalcoholic fatty liver disease (NAFLD) is associated with major
abnormalities of hepatic lipid metabolism. We propose that lipid abnormalities directly or …

AMPK and mTOR play principal roles in governing metabolic programs; however,
mechanisms underlying the coordination of the two inversely regulated kinases remain …

Membrane trafficking between organelles by vesiculotubular carriers is fundamental to the
existence of eukaryotic cells. Central in ensuring that cargoes are delivered to their correct …

▪ Abstract Phagocytosis of pathogens by macrophages initiates the innate immune
response, which in turn orchestrates the adaptive response. In order to discriminate between …

Live-cell imaging reveals the endolysosomal system as a complex and highly dynamic
network of interacting compartments. Distinct types of endosomes are discerned by kinetic …