Membrane trafficking between organelles by vesiculotubular carriers is fundamental to the
existence of eukaryotic cells. Central in ensuring that cargoes are delivered to their correct …

▪ Abstract Phagocytosis of pathogens by macrophages initiates the innate immune
response, which in turn orchestrates the adaptive response. In order to discriminate between …

Cellular organelles in the exocytic and endocytic pathways have a distinctive spatial
distribution and communicate through an elaborate system of vesiculo-tubular transport …

Small GTP-binding proteins (G proteins) exist in eukaryotes from yeast to human and
constitute a superfamily consisting of more than 100 members. This superfamily is …

Cell-to-cell communication is a crucial prerequisite for the development and maintenance of
multicellular organisms. To date, diverse mechanisms of intercellular exchange of …

We have investigated the in vivo functional role of rab5, a small GTPase associated with the
plasma membrane and early endosomes. Wild-type rab5 or rab5-ile133, a mutant protein …

Mammalian cells take up extracellular material by a variety of different mechanisms that are
collectively termed endocytosis. Endocytic mechanisms serve many important cellular …

Of the approximately 70 human Rab GTPases, nearly three-quarters are involved in
endocytic trafficking. Significant plasticity in endosomal membrane transport pathways is …

The synaptic vesicle cycle at the nerve terminal consists of vesicle exocytosis with neuro-
transmitter release, endocytosis of empty vesicles, and regeneration of fresh vesicles. Of all …

GTPases and lipid kinases regulate membrane traffic along the endocytic pathway by
mechanisms that are not completely understood,,,. Fusion between early endosomes …