Margins in breast cancer: How much is enough?

M Pilewskie, M Morrow - Cancer, 2018 - Wiley Online Library
The appropriate negative margin width for women undergoing breast‐conserving surgery for
both ductal carcinoma in situ (DCIS) and invasive carcinoma is controversial. This review …

Intraoperative margin management in breast-conserving surgery: a systematic review of the literature

RJ Gray, BA Pockaj, E Garvey, S Blair - Annals of surgical oncology, 2018 - Springer
Background Breast surgeons have a wide variety of intraoperative techniques available to
help achieve low rates for positive margins of excision, with variable levels of evidence …

Variability in reexcision following breast conservation surgery

LE McCahill, RM Single, EJA Bowles, HS Feigelson… - Jama, 2012 - jamanetwork.com
Context Health care reform calls for increasing physician accountability and transparency of
outcomes. Partial mastectomy is the most commonly performed procedure for invasive …

Repeat surgery after breast conservation for the treatment of stage 0 to II breast carcinoma: a report from the National Cancer Data Base, 2004-2010

LG Wilke, T Czechura, C Wang, B Lapin… - JAMA …, 2014 - jamanetwork.com
Importance Although complete excision of breast cancer is accepted as the best means to
reduce local recurrence and thereby improve survival, there is currently no standard margin …

A randomized prospective study of lumpectomy margin assessment with use of MarginProbe in patients with nonpalpable breast malignancies

F Schnabel, SK Boolbol, M Gittleman, T Karni… - Annals of surgical …, 2014 - Springer
Background The presence of tumor cells at the margins of breast lumpectomy specimens is
associated with an increased risk of ipsilateral tumor recurrence. Twenty to 30% of patients …

Trends in reoperation after initial lumpectomy for breast cancer: addressing overtreatment in surgical management

M Morrow, P Abrahamse, TP Hofer, KC Ward… - JAMA …, 2017 - jamanetwork.com
Importance Surgery after initial lumpectomy to obtain more widely clear margins is common
and may lead to mastectomy. Objective To describe surgeons' approach to surgical margins …

Mesoporous silica nanoparticles as a breast-cancer targeting ultrasound contrast agent

A Milgroom, M Intrator, K Madhavan, L Mazzaro… - Colloids and Surfaces B …, 2014 - Elsevier
Ultrasound (US) is used widely in the context of breast cancer. While it is advantageous for a
number of reasons, it has low specificity and requires the use of a contrast agent. Its use as a …

Reasons for Re-Excision After Lumpectomy for Breast Cancer: Insight from the American Society of Breast Surgeons MasterySM Database

J Landercasper, E Whitacre, AC Degnim… - Annals of surgical …, 2014 - Springer
Background There is marked variability of re-excision rates after initial lumpectomy for breast
cancer. Reasons for re-excision and variability across surgeons have not been well …

Tumor characteristics as predictors of local recurrence after treatment of ductal carcinoma in situ: a meta-analysis

SY Wang, T Shamliyan, BA Virnig, R Kane - Breast cancer research and …, 2011 - Springer
While ductal carcinoma in situ (DCIS) is seldom life threatening, the management of DCIS
remains a dilemma for patients and their physicians. Aggressive treatment reduces the risk …

Rapid histopathological imaging of skin and breast cancer surgical specimens using immersion microscopy with ultraviolet surface excitation

T Yoshitake, MG Giacomelli, LM Quintana, H Vardeh… - Scientific reports, 2018 - nature.com
Rapid histopathological evaluation of fresh, unfixed human tissue using optical sectioning
microscopy would have applications to intraoperative surgical margin assessment …