Biomarkers for neurodegenerative diseases

O Hansson - Nature medicine, 2021 - nature.com
Biomarkers for neurodegenerative diseases are needed to improve the diagnostic workup in
the clinic but also to facilitate the development and monitoring of effective disease-modifying …

Fusion of medical imaging and electronic health records using deep learning: a systematic review and implementation guidelines

SC Huang, A Pareek, S Seyyedi, I Banerjee… - NPJ digital …, 2020 - nature.com
Advancements in deep learning techniques carry the potential to make significant
contributions to healthcare, particularly in fields that utilize medical imaging for diagnosis …

Plasma P-tau181 in Alzheimer's disease: relationship to other biomarkers, differential diagnosis, neuropathology and longitudinal progression to Alzheimer's dementia

S Janelidze, N Mattsson, S Palmqvist, R Smith… - Nature medicine, 2020 - nature.com
Plasma phosphorylated tau181 (P-tau181) might be increased in Alzheimer's disease (AD),
but its usefulness for differential diagnosis and prognosis is unclear. We studied plasma P …

Blood phospho-tau in Alzheimer disease: analysis, interpretation, and clinical utility

TK Karikari, NJ Ashton, G Brinkmalm… - Nature Reviews …, 2022 - nature.com
Well-authenticated biomarkers can provide critical insights into the biological basis of
Alzheimer disease (AD) to enable timely and accurate diagnosis, estimate future burden and …

Multimodal deep learning for Alzheimer's disease dementia assessment

S Qiu, MI Miller, PS Joshi, JC Lee, C Xue, Y Ni… - Nature …, 2022 - nature.com
Worldwide, there are nearly 10 million new cases of dementia annually, of which
Alzheimer's disease (AD) is the most common. New measures are needed to improve the …

The Alzheimer's Association appropriate use recommendations for blood biomarkers in Alzheimer's disease

O Hansson, RM Edelmayer, AL Boxer… - Alzheimer's & …, 2022 - Wiley Online Library
Blood‐based markers (BBMs) have recently shown promise to revolutionize the diagnostic
and prognostic work‐up of Alzheimer's disease (AD), as well as to improve the design of …

Pathology of neurodegenerative diseases

BN Dugger, DW Dickson - Cold Spring Harbor …, 2017 - cshperspectives.cshlp.org
Neurodegenerative disorders are characterized by progressive loss of selectively vulnerable
populations of neurons, which contrasts with select static neuronal loss because of …

Biomarkers for Alzheimer's disease: current status and prospects for the future

K Blennow, H Zetterberg - Journal of internal medicine, 2018 - Wiley Online Library
Accumulating data from the clinical research support that the core Alzheimer's disease (AD)
cerebrospinal fluid (CSF) biomarkers amyloid‐β (Aβ42), total tau (T‐tau), and …

Blood‐based biomarkers for Alzheimer's disease

A Leuzy, N Mattsson‐Carlgren, S Palmqvist… - EMBO molecular …, 2022 - embopress.org
Neurodegenerative disorders such as Alzheimer's disease (AD) represent a mounting public
health challenge. As these diseases are difficult to diagnose clinically, biomarkers of …

Amyloid-PET and 18F-FDG-PET in the diagnostic investigation of Alzheimer's disease and other dementias

G Chételat, J Arbizu, H Barthel, V Garibotto… - The Lancet …, 2020 - thelancet.com
Various biomarkers are available to support the diagnosis of neurodegenerative diseases in
clinical and research settings. Among the molecular imaging biomarkers, amyloid-PET …